Optimal space coverage algorithm for pancreatic tumor ablation with irreversible electroporation
Objective In traditional ablation surgery,doctors roughly estimate the size,location,and shape of the tumor by observing the patient's two-dimensional images,in order to plan the surgical plan.This method heavily relies on the subjective experience and professional skills of doctors,which can easily lead to excessive or incomplete ablation,increasing the risk of postoperative complications.Therefore,scientific preoperative planning and precise localization of ablation electrodes and electric field action areas are of great significance.This article proposes an optimal space coverage model algorithm for pancreatic tumors,which provides the optimal electric field action area for irreversible electroporation ablation of pancreatic tumors.Methods Based on the fact that the electric field ablation area generated by a single bipolar high-voltage pulse electrode is an ellipsoid,under the constraint that the direction of the long axis of the ellipsoid is the same as the direction of the electrode introduction path,the center of the ellipsoid is on the pancreatic duct and the length of the long and short axis meets a certain proportion,the Active-Set algorithm is used to solve the center of the ellipsoid,and then Rodrigues rotation is used to solve the positive definite matrix.The ellipsoid obtained is the electric field action area.After that,the ratio of long axis to short axis is iteratively optimized.Finally,the proportion of tumor in the ellipsoid is used as an evaluation index to find the minimum ablation ellipsoid,that is,the optimal electric field action area.Extensive experiments are carried out on MSD dataset to find the smallest ablation ellipsoid and proportion of tumors of each case.Results The minimal ablation ellipsoid is closely related to the geometric shape of the tumor and its location from the pancreatic duct.For most cases,the proportion of tumors in the minimal ablation ellipsoid is between 20%and 50%,and the maximum is 59.5%.Conclusions The algorithm proposed in this paper can provide a feasible theoretical basis for the optimal electric field ablation area of irreversible electroporation ablation of pancreatic tumors,and assist clinicians in making efficient decisions.
pancreatic tumorirreversible electroporationpreoperative planningoptimal space coverageminimally invasive ellipsoid
万方数据
维普
