Study on the improvement of mechanical properties and antibacterial properties of chitosan hydrogels based on copper ion crosslinking
Objective Chitosan(CTS)molecules can gradually form reticular chitosan hydrogels(CTS/NH3)through chain entanglement and the interaction of low-energy bonds between molecules(such as hydrogen bonds,coordination bonds,etc.)in alkaline atmosphere(NH3),but its mechanical properties are poor and its biological antibacterial activity is low.This paper intends to improve its related properties by adding copper ions.Methods With CuCl2 and CTS as raw materials,2.5 g of chitosan was added into 100 mL of 2%acetic acid aqueous solution,and the concentration of chitosan was 2.5%(mass fraction).Then a certain amount of copper chloride was added to the chitosan solution to form chitosan-CuCl2 solution.The chitosan CuCl2 solution was cross-linked in a closed ammonia atmosphere of 0.2 m3.Let stand for 12 h until the hydrogel forms.The hydrogel was removed from the petri dish and washed with distilled water until the washing solution was neutral.Chitosan-copper ionized hydrogels with different concentrations of copper ions were prepared,and their mechanical properties and bioantibacterial activities were tested.Results Copper ion endowed chitosan hydrogel with good swelling properties and stable rheological properties,so that its mechanical properties were significantly improved,and with the increase of copper ion concentration,the mechanical properties were more excellent.At the same time,copper ions also made chitosan hydrogels show better antibacterial properties,so that it has the potential to cure the wound infection of this kind of bacteria.Conclusions Copper ions can effectively improve the mechanical properties and antibacterial properties of chitosan hydrogels,and make it have the prospect of application as biomedical dressings and the potential application value in biomedicine penetrating wound.
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