Construction and numerical simulation of neointimal remodeling model under multiple mechanical stimulation
Objective The implantation of stents causes endothelial injury in blood vessels,leading to neointimal remodeling. This article aims to construct a model of neointimal remodeling under mechanical stimulation after stent implantation, explore the effects of arterial stress and wall shear stress on neointimal remodeling, and investigate the distribution of vascular stress during the neointimal remodeling process. Methods A stent implantation model and a blood flow model in the stent segment were established to calculate the mechanical stimulation on the vessel wall after stent implantation. The relationship between mechanical stimulation and cell proliferation was described by growth factor g,and a cell proliferation and migration model was constructed to simulate the process of cell aggregation forming the neointima. The neointimal remodeling process was simulated separately under arterial stress and wall shear stress to explore the differences in the effects of the two mechanical stimulations. The changes in vascular stress distribution during the neointimal remodeling process under the combined effects of arterial stress and wall shear stress were also obtained. Results Under arterial stress, the neointima was concentrated in the stent segment,with a greater impact on the lumen of the stent segment. Under wall shear stress, the neointimal remodeling range was wider, including both upstream and downstream of the stent segment. Neointimal remodeling reduced the peak and high-stress areas of vascular wall stress,with the peak stress value decreasing from 0. 277 MPa to 0. 098 MPa, and the volume of high-stress areas decreasing by 64. 6％ after remodeling. Conclusions The neointimal remodeling model can capture the dynamic changes in vascular morphology and stress after stent implantation. Different mechanical stimulations lead to significant differences in the neointima location and remodeling speed,with distinct features. The neointima can provide a certain degree of support to the vascular wall,leading to a significant reduction in high-stress areas of the vascular wall.
万方数据
维普
