Research progress on the role of SDF-1/CXCR4 signal axis in MSCs repairing injured tissues
Bone marrow-derived mesenchymal stem cells (MSCs) have a self-renewal capacity and multilineage differentiation potential, and play an important role in the repair of injured tissue. Stromal cell-derived factor-1 (SDF-1)/CXC chemokine receptor 4 (CXCR4) signal axis is a coupled molecular pair formed by the interaction between SDF-1 and CXCR4,which can carry out signal transduction,induce cell migration, and participate in a variety of biological processes of cells. Studies have confirmed that SDF-1/CXCR4 signal axis plays a pivotal role in promoting chemotaxis and proliferation in MSCs-mediated tissue repair of myocardial ischemia,kidney disease,and bone tissue injury and so on. This review paper briefly introduces the molecular structure of SDF-1 and CXCR4,then discusses the role of SDF-1/CXCR4 signal axis in MSCs-mediated repair of related injured tissue. Finally, we summarize the research progress and prospect the future development directions in this field. This review provides a theoretical basis for better understanding of SDF-1/CXCR4 axis and its role in MSCs-mediated tissue repair, and brings a reference for better application of MSCs in tissue repair in clinic.
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维普
