Objective To achieve a personalized numerical simulation of counterpulsation mode feedback regulation in enhanced external counterpulsation (EECP) for different patients with better hemodynamic effects.Methods The influence mechanism of EECP counterpulsation mode on different indications is studied through the simulation of lumped parameter model.According to the feedback regulation principle of PID control system,it is applied in the study of EECP.The closed-loop 0 dimensional centralized parameter model of blood circulation system is taken as the controlled object for personalized external counterpulsation hemodynamic simulation.In combination with the evaluation model of local hemodynamic effects of extracorporeal counterpulsation,optimized personalized target values are set for patients with different indications (coronary heart disease or stroke) .According to the error between the set target value and the current hemodynamic indicator,different counterpulsation modes (pressure amplitude or pressure duration) can be adjusted by setting appropriate proportion,integral and differential gain coefficients and the error to make the current hemodynamic index reach the set target value.Results The increase of pressure amplitude on the coronary hemodynamic index is more obvious.Pressure duration has the most significant effect on the hemodynamic effect of cerebral artery.Therefore,the optimal target value of diastolic blood pressure/systolic blood pressure (D/S) is set for patients with coronary heart disease,and the current D/S reaches the set D/S through feedback adjustment of pressure amplitude,and the absolute value of error between them is finally reduced to 0.06 (average<5％),and the counterpulsation pressure is got at this time.For stroke patients with a target value of cerebral blood flow (CBF),the input pressure duration of the system is adjusted to reduce the error,and the current CBF of the output of the control system to reach the set CBF,reducing the absolute value of the error to 0.06 (average<5％) and the pressure duration is obtained at this time.Conclusions When the hemodynamic indicators in numerical simulation reach the optimization target value,the counterpulsation pressure and pressure duration can provide theoretical basis for the clinical in EECP optimization treatment.
关键词
体外反搏/血流动力学效应优化/PID控制系统/反馈调控/数值模拟
Key words
enhanced external counterpulsation/optimization of hemodynamic effects/PID control system/feedback control/numerical simulation
维普
万方数据