Design of an ultrasonic probe for animal experiment of urethral scar prevention
Objective Urethral scar is one of the common complications after urethral surgery for patients,and it is difficult to remove by surgical treatment.Low-intensity pulsed ultrasound (LIPUS) has shown outstanding performance in inhibiting fibrosis and suppressing inflammation,providing theoretical possibilities for ultrasonic prevention and treatment of urethral scar.However,there is no report on the prevention and treatment of urethral scar by ultrasound at present,and the mechanism of ultrasound in inhibiting fibrosis and inflammation still needs further study.We design an ultrasound probe for the urethral reconstruction model of New Zealand male rabbits,which is used for animal experimental research on the efficacy and mechanism of LIPUS (low-intensity pulsed ultrasound) in inhibiting urethral scar.Methods The structure of the ultrasound probe is determined by the size and shape of the rabbit penis.The probe sound field is predicted through finite element simulation.The 3D printing technology is used to manufacture prototypes.Finally,the sound field of the probe is tested and used in animal experiments to verify its practicality.Results The ultrasonic frequency of the probe is 2 MHz,the length of the treatment chamber is 44 mm,and the diameter is 8 mm.There are three adjacent treatment areas along the length direction of the treatment cavity,the half power lenth of each area is about 6 mm.Isata(time average spatial average sound intensity) in the treatment area can be regulated by the power supply voltage which is more than 0.87 W/cm2 when the voltage is 30 V.Conclusions The ultrasonic probe designed in this paper has small size,light weight and uniform sound field,which can carry out stable and effective ultrasonic irradiation on the animal urethra,and provides a useful tool for the animal experiment of ultrasonic treatment of urethral scar.
low intensity pulse ultrasoundurethral scarultrasonic probeultrasonic therapyfinite element simulation
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