摘要
目的 探寻神经组织特异性基因对肥胖的作用及机制,希望有助于开发新的疾病干预和治疗措施.方法 通过检索、查阅和筛选与"synphilin-1、Ets96B、Alk、Dgk、肥胖和运动"等相关的文献,分析和比较文献之间的异同点,理清相关指标间的关系.结果与结论 synphilin-1、Ets96B、Alk、Dgk在神经组织中表达富集,其在神经组织差异性表达可诱发机体肥胖,并且与机体的运动能力存在关联.4种神经组织特异性基因诱发机体肥胖均是通过某种信号通路来实现的.这可为未来肥胖发病机制和治疗方法的研究提供一个新思路.
Abstract
Purposes—To explore the effect and mechanism of neural tissue-specific genes on obesi-ty,in hopes of the contribution to the development of new disease interventions and treatments.Methods—By retrieving,consulting and screening relevant literature on"synphilin-1,Ets96B,Alk,Dgk,obesity and exercise",the similarities and differences between the literature were analyzed and compared,with the relationship between relevant indicators clarified.Results and Conclusions—Syn-philin-1,Ets96B,Alk and Dgk are highly expressed in neural tissues,and their differential expression in neural tissues can induce obesity in the body,and is also associated with the motor ability of the body.The four neural-tissue-specific genes induce obesity through some signaling pathway.This may provide a new idea for the study of pathogenesis and treatment of obesity in the future.
基金项目
国家自然科学基金-青年科学基金项目(32000832)
鲁东大学研究生创新项目(IPGS2024-032)
维普
万方数据