Purposes—To briefly summarize the research status of D-type trichothecenes and their anticancer activity,and to provide lead compounds for the development of new anticancer drugs.Methods—The D-type trichothecenes and their anticancer activities were reviewed by reference to rele-vant literature reported in recent years.Results—The structural features of trichothecenes are sketched out and the reported D-type trichothecenes and their anticancer activities are summarized.Conclusions—97 D-type trichothecenes and their anticancer activities are reviewed hereof,with the structure-activity relationship of some compounds preliminarily discussed,thus laying the foundation for further development of such small molecules for the treatment of cancer.
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