基于神经血管单元稳态探讨偏头痛的气血病机
Traditional Chinese medicine pathogenesis of qi and blood in migraine based on homeostasis of the neurovascular unit
李丹溪 1任北大 1韩芳 2曹克刚1
作者信息
- 1. 北京中医药大学东直门医院 北京 100700;北京中医药大学中医脑病研究院
- 2. 首都医科大学附属北京中医医院
- 折叠
摘要
偏头痛是临床多发的慢性发作性神经血管疾病,具有明显的"发作-缓解"特征,发病机制尚不完全清楚.中医学理论中,偏头痛属"头痛""头风"等疾病范畴,气血失调是其发病基础,气虚血瘀是其重要病机.神经血管单元的生理功能与气血密切相关.本文围绕神经血管单元这一研究热点,从微环境稳态失调及各细胞成分交互作用的角度,梳理脑微观气血理论的生理基础,阐释偏头痛的气血病机的科学内涵.神经血管单元微环境稳态失调,参与偏头痛病理机制,契合偏头痛气血病机,主要体现在气虚固摄失权、卫外失司、气化失常,以及邪毒积聚、瘀血阻滞等方面.基于神经血管单元稳态对偏头痛的气血病机进行深入理解,有助于全面把握偏头痛疾病发展规律,可为中医药从气血论治偏头痛提供理论指导,并为偏头痛的中医药防治研究提供新的思路.
Abstract
Migraine is a chronic episodic neurovascular disease with a distinct"episode-remission"feature.According to the theory of traditional Chinese medicine,migraine belongs to the class of diseases including"Toutong"and"Toufeng".Disorder of qi and blood,especially blood stasis due to qi deficiency,lie at the basis of migraine pathogenesis.The physiological function of the neurovascular unit is strongly related to qi and blood.Focusing on the neurovascular unit,this paper expounds the physiological basis of the theory of qi and blood from the perspective of microenvironment homeostatic disorder and the interaction of various cell components,and discusses the scientific connotation of the pathogenesis of qi and blood in migraine.Disordered homeostasis of the neurovascular unit is involved in the pathology of migraine and tallies with the pathogenesis of qi and blood in migraine,which is mainly reflected in dysfunction of astringing,defending,and transforming due to qi deficiency,as well as pathogenic toxin accumulation and blood stasis.The explanation based on homeostasis of the neurovascular unit due to qi and blood pathogenesis in migraine is helpful to understand the development of migraine integrally and to provide guidance for traditional Chinese medicine treatment and research of migraine from the theory of qi and blood.
关键词
偏头痛/神经血管单元/气血理论/病机/气虚血瘀Key words
migraine/neurovascular unit/theory of qi and blood/pathogenesis/blood stasis due to qi deficiency引用本文复制引用
基金项目
国家自然科学基金青年项目(82205031)
北京中医药大学基本科研业务费项目(2021-JYB-XJSJJ062)
出版年
2024
国家科技期刊平台
NSTL
维普
万方数据