基于颗粒细胞自噬从"气"探讨早发性卵巢功能不全的辨治
Analysis on the differentiation and treatment of premature ovarian insufficiency from"qi"based on granulosa cell autophagy
李广慧 1冯晓玲2
作者信息
- 1. 黑龙江中医药大学 哈尔滨 150040
- 2. 黑龙江中医药大学附属第一医院
- 折叠
摘要
早发性卵巢功能不全属中医学"经水早断""血枯""不孕症"等疾病范畴,不仅影响女性生育能力,使其过早进入围绝经期状态,还增加女性骨质疏松、认知障碍及心血管疾病等远期并发症的发病风险.细胞自噬对卵泡发育及闭锁具有双重调节作用,与早发性卵巢功能不全的发病密切相关.女子以血为本、以气为用.本文从"气"立论,认为早发性卵巢功能不全的病机以脏腑气虚、胞宫失养为本,脏腑气郁、胞脉闭阻为标,并从本病发病中的自噬与气的相关性为切入点,提出补气为基、行气为要的治疗原则.中医内外治法通过"调气"可纠正颗粒细胞自噬异常,改善卵巢微环境,保护卵巢功能,进而防治早发性卵巢功能不全.
Abstract
Premature ovarian insufficiency belongs to the category of early menstrual cessation,blood depletion,and infertility in traditional Chinese medicine,which not only affects women's fertility and forces them into a premature perimenopausal period,but also increases the risk of long-term complications such as osteoporosis,cognitive impairment,and cardiovascular diseases.Autophagy has a dual regulatory effect on follicular development and atresia,closely related to the onset of premature ovarian insufficiency.In women,blood is the basis and qi is the use.This article argues from the perspective of"qi",positing that the pathogenesis of premature ovarian insufficiency is fundamentally due to the deficiency of qi in the zang-fu organs leading to inadequate nourishment of the uterus,while the obstruction of the uterine vessels by qi depression in the zang-fu organs as manifestation.It also takes the correlation between autophagy and qi in the onset of premature ovarian insufficiency as the starting point,proposing a therapeutic principle centered on replenishing qi as the foundation and activating qi as the key.The internal and external treatment of traditional Chinese medicine can correct the abnormal autophagy of granulosa cells through"regulating qi",thus improving the ovarian microenvironment,protecting the ovarian function,and finally preventing and treating premature ovarian insufficiency.
关键词
早发性卵巢功能不全/细胞自噬/气虚/气郁/调气Key words
premature ovarian insufficiency/autophagy/qi deficiency/qi stagnation/regulating qi引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据