Patients with moderate myopia were divided into group A(-3.00 D≤subjective sphericity≤-4.00 D)and group B(-4.00 D<subjective sphericity≤-5.00 D)based on baseline subjective sphericity.Ophthalmic examinations of the baseline period,follow-up at 1 day,1 week,1 month and 3 months after wearing OK lens were done.The results showed that at each follow-up time point,the UDVA of both groups of patients significantly improved compared to the baseline period(P<0.05).At 1 month,the proportion of patients in both groups who achieved 0.1 logMAR(Decimal visual acuity 0.8)of UDVA was 88.9%and 90.6%,respectively;Three months after wearing OK lens,there was no statistically significant difference in the subjective refraction of spherical,cylinder,and diopter between the two groups of patients(P>0.05),and there was a significant decrease compared to the baseline period(P<0.05).The amount of change in group B was higher than that in group A(P<0.05).Wearing NOR aspherical OK lenses in patients with moderate myopia can effectively improve UCDVA,reduce refractive power,and do not affect intraocular pressure and corneal endothelial cells.The lens matching is really high,with fewer complications,and it is safe and reliable to use in conjunction with hydrogen peroxide care solution.