Lubricating,Antimicrobial Zwitterionic/Cationic Polymer Brush Coatings Prepared by Simple Methods
Urethral catheters are indispensable medical devices for patients with urinary incontinence,urinary retention,and other urinary disorders.However,the outer surface of the catheter currently faces the problem of urinary tract infection in patients due to bacterial adherence.In addition,in clinical treatment,catheters need to be in frequent contact with body tissues either for a long or short period of time.And due to the large friction coefficient between the surface of the catheter and muscle tissues,the patient will experience varying degrees of burning pain each time when the tissues are inserted or withdrawn,which is prone to cause the corresponding mucosal damage and even tissue inflammation.Therefore,the development of catheters that are antimicrobial,inhibit bacterial aggregation and biofilm attachment,and have a lubricating effect,which is an urgent problem that needs to be solved.In order to avoid bacterial infections and friction damage complications that may occur when using urinary catheters.This paper described the development of a novel polymer brush antimicrobial coating strategy.This strategy copolymerized methacryloyloxyethyl sulfobetaine(SBMA)zwitterionic material and methacryloyloxyethyl trimethyl ammonium chloride(DMC)cationic material to form a polymer brush coating.This strategy combined the passive antimicrobial principle of resisting bacterial adhesion and the active antimicrobial principle of killing bacteria.Various PSBMA/DMC polymeric brush coatings were synthesized by a single-step polymerization process,in which the SBMA and DMC monomers were polymerized by UV-initiated grafting,and the molar ratios of SBMA and DMC in the polymerized monomer solutions were varied.The wettability,lubricity,protein adhesion resistance and antibacterial effect of each polymer brush coat were characterized and compared by surface water contact angle test,atomic force microscopy friction test,protein adhesion test and bacterial adhesion test,respectively.The test results showed that an increase in the SBMA content in the PSBMA/DMC coatings was associated with enhanced surface wettability,and the water contact angle of the PSBMA/DMC-100 coatings was reduced to 27.6°.In addition,the increase in SBMA content in PSBMA/DMC coatings was also associated with enhanced surface lubricity,and the coefficient of friction of the PSBMA/DMC-100 coating was reduced to 0.019 7,which was 94％lower compared with the TPU surface.In addition,the antimicrobial effect of different PSBMA/DMC coatings varied.A large number of live and dead bacteria were attached to the untreated TPU surface,while the adhesion of bacteria to the surface was reduced after the coating treatment.Overall,the total bacterial adhesion decreased as the SBMA content of the PSBMA/DMC polymer brush coating increased.In contrast,the higher the DMC content in the PSBMA/DMC polymer brush coating,the higher the percentage of dead bacteria among the adhered bacteria.The number of bacteria adhering to the surface of the PSBMA/DMC-100 polymer brush coating containing only SBMA decreased by 96.1％.However,the small amount of attached bacteria were live bacteria,which was detrimental to the long-lasting antimicrobial performance of the coating.In contrast,the PSBMA/DMC-25 hybrid polymer brush coating consisting of 25％SBMA and 75％DMC demonstrated effective antimicrobial performance by integrating active and passive antimicrobial strategies.This resulted in a 92％reduction in bacterial adhesion and complete killing of all adhering bacteria,showing potential for long-term antimicrobial activity.In conclusion,the polymer brush coatings mixed with zwitterionic and cationic materials are simple to prepare.It combines active and passive antimicrobial strategies,and balances surface lubrication properties and antimicrobial performance,which is expected to solve the problems of bacterial infections and friction damages faced by urinary catheters,and has a potential application in the field of surface coatings for related medical devices.
万方数据
维普
