Prognostic significance of procalcitonin,D-dimer and N-terminal pro-brain natriuretic peptide in patients with severe acute exacerbation of chronic obstructive pulmonary disease
Objective:To investigate the Prognostic significance of procalcitonin,D-dimer and N-terminal pro-brain natriuretic peptide(NT-proBNP)in patients with severe acute exacerbation of chronic obstructive pulmonary dis-ease(AECOPD).Methods:The clinical data of 102 patients with severe AECOPD were analyzed retrospectively.The patients were divided into poor prognosis group(36 cases)and good prognosis group(66 cases)based on different prog-noses.The procalcitonin,D-dimer and NT-proBNP were detected and compared between the two groups.Logistic re-gression analysis was used for multivariate analysis and ROC curve was used to evaluate the prognostic value.Results:The concentrations of procalcitonin,D-dimer and NT-proBNP in the poor prognosis group were significantly higher than those in the good prognosis group(P＜0.01).The P values of procalcitonin,D-dimer and NT-proBNP in logis-tic regression analysis were all lower than 0.05.AUC of procalcitonin,D-dimer and NT proBNP were 0.743,0.778 and 0.708 respectively(P＜0.01).AUC of procalcitonin combined with D-dimer,procalcitonin combined with NT-proBNP,D-dimer combined with NT proBNP were 0.847,0.815 and 0.798,respectively(P＜0.01).The AUC of Joint testing of three indicators was 0.862(P＜0.01).Conclusion:Procalcitonin,D-dimer and NT-proBNP are in-dependent risk factors for poor prognosis of severe AECOPD,which have certain predicting value in the prognosis of se-vere AECOPD,and the combined detection of the three could achieve the best prognostic effect.
NETL
NSTL
万方数据
