Clinical characteristics of nonalcoholic fatty liver complicated with type 2 diabetes mellitus
Objective:To explore the correlation of metabolic indexes between nonalcoholic fatty liver disease(NAFLD)and type 2 diabetes mellitus(T2DM).Methods:From March 2020 to June 2021,704 patients who were hospitalized in the Department of Endocrinology,First Affiliated Hospital of Inner Mongolia University of Science and Technology and had complete records were selected,including type 2 diabetes patients with NAFLD and those without NAFLD,which are divided into the obesity group(BMI≥28 kg/m2),overweight group(24 kg/m2≤BMI＜28 kg/m2)and normal weight group(BMI＜24 kg/m2)according to different body mass indexes.The general data of different groups of T2DM with NAFLD and T2DM without NAFLD were compared and the insulin resistance indexes(HOMA-IR)were calculated.Results:There were significant differences in VFA,ApoB,DBIL,ALT,AST,UA,FCP,FINS and HOMA-IR among the three groups of T2DM patients complicated with NAFLD of different body mass indexed and(P＜0.05).The levels of BMI,VFA,TG,TC,ALT,AST,γ-GGT,DBIL,IBIL,UA,FPG,HbA1c,FCP,FINS and HOMA-IR in T2DM patients complicated with NAFLD were significantly higher than those without NAFLD,but the ages and HDL in T2DM patients complicated with NAFLD were smaller,and the differences were sta-tistically significant(P＜0.05).The course of diabetes,gender differences and the prevalence of hypertension in each group had no significant influence on NAFLD,and the differences were not statistically significant(P＞0.05).Multiva-riate Logistic regression analysis showed that BMI,VFA,HbA1c,FCP,HOMA-IR,TG,APOB,ALT,γ-GGT and UA were independent risk factors for NAFLD.Conclusion:Obesity and metabolic disorder of glucose and lipid are the initiators of NAFLD,and these patients are getting younger.In addition,this kind of people is also more likely to devel-ope other metabolic syndromes
Non-alcoholic fatty liverType 2 diabetes mellitusObesityMetabolic index
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