Strain distribution and drug susceptibility analysis of 295 VVC isolates in Baotou area
Objective:to investigate the distribution of candidiasis in patients with vulvovaginal can-didiasis(VVC)in Baotou area and the susceptibility to antifungal drugs,so as to provide reference for accurate clinical treatment.Methods:The vaginal secretions of 295 patients with VVC from January to December 2021 were collected for isolation and culture.MALDI-TOFMS and PCR were used to com-plete the identification of strains.According to the CLSI M27-S4 standard,the in vitro drug sensitivity test of 9 drugs was carried out by microbroth dilution method.Results:The patients with infection were most common in the 31-35 age group(30.85%),followed by the 26-30 age group(20.34%),and the 21-40 age group accounted for 82.04%.Sexual life,pregnancy and other susceptible factors ac-counted for a large proportion in VVC.A total of 295 non-repetitive strains were isolated and identi-fied,of which Candida albicans ranked the first(79.32%),followed by Candida glabrata(13.90%),and 7 rare Candida species such as Nivalia and Bugala(1 strain in each).The resistance rate of Candi-da albicans to itraconazole was higher than that of non-Candida albicans(P＜0.01),while there was no significant difference in the resistance of fluconazole,voriconazole and posaconazole between the two groups(P＞0.05).The resistance rate of non-Candida albicans to caspofungin and 5-fluorocytosine was higher than that of Candida albicans(P＜0.01).No nystatin-resistant strains were found.The sensitivity of all strains to amphotericin B was 100%,and the resistance rate to terbinafine was high.Conclusion:VVC patients in Baotou area are infected with various strains,especially Candida albicans,but the susceptibility of different strains to common antifungal drugs is quite different.Regular and con-tinuous drug resistance monitoring should be carried out to guide gynecologists to formulate correct diag-nosis and treatment plans and delay the emergence of drug resistance.
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维普
