Objective:To further investigate the effect of impaired glucose regulation on deceleration capacity of heart rate(DC),heart rate deceleration runs(DRs)and prognosis in patients with chronic heart failure.Methods:A total of 116 patients with chronic heart failure and impaired glucose regulation were selected,including 65 patients with chronic heart failure and impaired glucose tolerance(IGT group),51 patients with chronic heart failure and impaired fasting glucose(IFG group),and 70 patients with chronic heart failure and normal blood glucose matched with age and sex were selected as the control group.The general clinical data,DC and DRs test results,and the incidence of cardio-vascular events were compared among the three groups.Results:In IGT group,the average heart rate and plasma N-terminal pro-B-type natriuretic peptide(NT-proBNP)increased,the left ventricular ejection fraction(LVEF)de-creased,the DC and DRs were significantly lower,and the incidence of cardiac death was significantly higher.There were significantly statistic differences compared with the other two groups(P＜0.05).Conclusion:The impairment of cardiac vagus nerve function in patients with chronic heart failure and IGT or IFG was more obvious than that in the nor-mal blood glucose group.The impairment of cardiac function in patients with chronic heart failure and IGT was the most serious,with significantly decreased DC and DRs indexes and worse prognosis.
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