包头医学院学报2024，Vol.40Issue(2) ：43-48.DOI:10.16833/j.cnki.jbmc.2024.02.008

脂蛋白(a)与前循环大动脉闭塞AIS血管内治疗患者临床结局的相关性

Association between lipoprotein(a)and clinical outcomes in patients treated with endovascular therapy for acute ischemic stroke due to anterior circulation large artery occlusion

王芳 郝喜娃 李月春
包头医学院学报2024，Vol.40Issue(2) ：43-48.DOI:10.16833/j.cnki.jbmc.2024.02.008
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  • 维普
  • 万方数据

脂蛋白(a)与前循环大动脉闭塞AIS血管内治疗患者临床结局的相关性

Association between lipoprotein(a)and clinical outcomes in patients treated with endovascular therapy for acute ischemic stroke due to anterior circulation large artery occlusion

王芳 1郝喜娃 2李月春2
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作者信息

  • 1. 包头医学院中心临床医学院,内蒙古 包头 014040
  • 2. 包头市中心医院
  • 折叠

摘要

目的:探讨脂蛋白(a)[Lp(a)]与前循环大动脉闭塞急性缺血性卒中(AIS)血管内治疗患者临床结局的相关性.方法:选择就诊于包头市中心医院神经内科发病24h内诊断为前循环大动脉闭塞急性缺血性卒中(AIS)并行血管内治疗(EVT)的患者,详细记录患者基线资料、血化验指标、手术相关信息、预后情况等.结局为EVT术后3 个月时预后良好的患者比例,预后良好定义为改良Rankin量表(mRs)评分0～2 分.采用SPSS 25.0 统计学软件对所有收集的数据进行分析,进一步评估Lp(a)与EVT患者临床结局的相关性.结果:共纳入265 例患者,其中预后良好组患者 141 例(53.2%),预后不良组患者 124 例(46.8%),预后良好组Lp(a)水平低于预后不良组,差异具有统计学意义,多因素Logistics回归分析显示Lp(a)OR =1.032;95%CI= 1.017～1.047.Lp(a)对EVT患者不良结局的ROC分析结果显示AUC =0.655;95%CI=0.590～0.721(P＜0.001),预测截断值为20.95 mg/dL,灵敏度为77.4%,特异度为51.1%.结论:Lp(a)水平与前循环大动脉闭塞急性缺血性卒中EVT患者术后 3 个月时的临床结局相关,并对其有一定的预测价值.

Abstract

Objective:To investigate the correlation between lipoprotein(a)[Lp(a)]and clinical outcome in patients with acute ischemic stroke with large artery occlusion in anterior circulation undergoing endovascular treatment.Methods:Patients diagnosed with acute ischemic stroke(AIS)with anterior circulation large artery occlusion within 24 hours of on-set and treated with endovascular treatment(EVT)in the Department of Neurology,Baotou Central Hospital were en-rolled.The baseline data,blood test indexes,operation related information,and prognosis of the patients were recorded in detail.The outcome was the proportion of patients with a good outcome at 3 months after EVT,defined as a modified Rankin scale(mRs)score of 0-2.SPSS 25.0 statistical software was used to analyze all collected data to further evaluate the correlation between Lp(a)and clinical outcomes of EVT patients.Results:A total of 265 patients were enrolled,in-cluding 141 patients(53.2%)in the good prognosis group and 124 patients(46.8%)in the poor prognosis group.The Lp(a)level in the good prognosis group was lower than that in the poor prognosis group,and the difference was statistical-ly significant.Multifactor logistic regression analysis showed Lp(a)OR=1.032;95%CI=1.017-1.047.ROC analysis of Lp(a)for poor outcomes in EVT patients showed that the AUC was 0.655(95%CI=0.590-0.721,P＜0.001),the predictive cut-off value was 20.95 mg/dL,the sensitivity was 77.4%,and the specificity was 51.1%.Conclusion:Lp(a)level is related to the clinical outcome at 3 months after EVT in patients with acute ischemic stroke with large artery occlusion in the anterior circulation,and has certain predictive value for its clinical outcome.

关键词

脂蛋白(a)/前循环大动脉闭塞/急性缺血性卒中/血管内治疗/临床结局

Key words

Lipoprotein(a)/Anterior Circulation Great Artery Occlusion/Acute Ischemic Stroke/Endovascular treatment/Clinical Outcome

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基金项目

包头市青年创新人才项目()

出版年

2024
包头医学院学报
内蒙古科技大学包头医学院

包头医学院学报

影响因子：0.543
ISSN：1006-740X
参考文献量20
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