Relationship between serum hypersensitivity C-reactive protein/albumin ratio,decoy receptor 3 and withdrawal outcome in patients with acute respiratory failure
Objective:To analyze the relationship between peripheral blood high-sensitivity C-reactive protein/albumin ratio(HCAR),decoy receptor 3(DcR3)and the outcome of weaning from mechanical ventilation in patients with acute respiratory failure.Methods:A total of 102 patients with acute respiratory failure who received mechanical ventilation from November 2020 to November 2021 were selected as the research objects.According to the outcome of weaning,they were divided into the weaning failure group(n =21)and the weaning success group(n =81).The peripheral blood HCAR and DcR3 levels were compared between the two groups before spontaneous breathing test(SBT)and after weaning,and the relationship between HCAR and DcR3 levels and the failure of weaning in pa-tients with acute respiratory failure was analyzed.The predictive value of weaning failure was analyzed,and the risk of weaning failure at different levels of HCAR and DcR3 was analyzed.Results:The lev-els of HCAR and DcR3 in peripheral blood before and after SBT in the weaning failure group were higher than those in the successful weaning group(P＜0.05).Logistic analysis showed that the levels of peripheral blood HCAR and DcR3 were significantly correlated with the failure of weaning in patients with acute respiratory failure.(P＜0.05);the combined prediction of peripheral blood HCAR and DcR3 levels before SBT and after weaning was better than independent prediction;the risk of weaning failure with high levels of peripheral blood HCAR and DcR3 before SBT and after weaning was low 1.125,1.633,1.893,2.236 times(P＜0.05).Conclusion:The levels of HCAR and DcR3 in pe-ripheral blood of patients with acute respiratory failure are increased,and the combination of these in-dicators can provide a reference for predicting the outcome of mechanical ventilation weaning in pa-tients with acute respiratory failure.
万方数据
维普
