摘要
目的:探讨中国老年糖尿病人群合并周围神经病变的主要危险因素.方法:计算机检索中国知网、万方、维普、中国生物医学文献数据库(CBM)、PubMed、Web of Science、EMbase、Cochrane Library数据库中关于中国老年糖尿病人群合并周围神经病变危险因素的相关文献,检索时限为建库至2022 年 10 月 11 日.采用Stata 12.0 进行Meta分析.结果:共纳入 12 篇文献,包括老年糖尿病患者合计3 492 例,合并周围神经病变患者2 057 例.Meta分析显示,中国老年糖尿病合并周围神经病变的危险因素包括年龄[OR =1.194,95%CI(1.111,1.283),P＜0.05]、病程[OR =1.756,95%CI(1.497,2.060),P＜0.05]、糖化血红蛋白(HbAlc)[OR =1.516,95%CI(1.244,1.848),P＜0.05]、总胆固醇(TC)[OR =1.323,95%CI(1.079,1.622),P＜0.05]、餐后2h血糖[OR =1.108,95%CI(1.056,1.163),P＜0.05].结论:影响中国老年糖尿病患者合并周围神经病变的危险因素有年龄、糖尿病病程、糖化血红蛋白、总胆固醇和餐后2h血糖,应从多个方面进行预防控制.
Abstract
Objective:To investigate the main risk factors of peripheral neuropathy in elderly Chi-nese patients with diabetes mellitus.Methods:Literature on risk factors of peripheral neuropathy in elderly Chinese patients with diabetes was searched from CNKI,Wanfang,VIP,CBM,PubMed,Web of Science,EMbase and Cochrane Library.The search time limit was from the establishment of the da-tabase to October 11,2022.The Stata12.0 software was used during the meta-analysis.Results:In all,12 studies were included,including 3492 elderly patients with diabetes and 2057 patients with pe-ripheral neuropathy.Meta-analysis indicated that risk factors for peripheral neuropathy in older Chi-nese patients with diabetes comprised age[OR =1.194,95%CI(1.111,1.283),P＜0.05],course of disease[OR =1.756,95%CI(1.497,2.060),P＜0.05],HbAlc[OR =1.516,95%CI(1.244,1.848),P＜0.05],TC[OR =1.323,95%CI(1.079,1.622),P＜0.05],and 2hPG[OR =1.108,95%CI(1.056,1.163),P＜0.05].Conclusion:Age,duration of diabetes,glycosylated hemoglo-bin,total cholesterol and blood sugar two hours after a meal are the risk factors of peripheral neuropa-thy in elderly patients with diabetes in China,which should be prevented and controlled from multiple aspects.
基金项目
安徽省高等学校省级质量工程项目(2016sjjd048)
安徽中医药大学研究生教育教学改革研究项目(2019YJG007)
安徽省研究生教育质量工程项目(2022hhsfkc030)
维普
万方数据