Causal association between vitamin D and hyperemesis gravidarum:a two-sample Mendelian randomization study
Objective:To study the causal relationship between vitamin D and hyperemesis gravi-darum by two-sample Mendelian randomization.Methods:Based on the IEU OpenGWAS project website,the GWAS data set of vitamin D with the largest sample size and the GWAS data set of hy-peremesis gravidarum were searched.The SNPs strongly associated with vitamin D were selected from the ieu-b-4808 library,and P＜5×10-8 with a linkage disequilibrium coefficient of 0.001 and a region width of 10 000 kb were set.SNPs associated with hyperemesis gravidarum were selected from finn-b-O15_EXCESS_VOMIT_PREG.The combined data set included 174 SNPs as instrumental variables.The association between vitamin D and hyperemesis gravidarum was analyzed by four regres-sion models:random effect inverse variance weighting(IVW),MR-Egger,weighted median,and weighted model.Results:The MR-Egger regression intercept was 0.005,and the corresponding P value was 0.513,suggesting that the SNPs had no gene pleiotropy.IVW regression results showed that OR(95%CIs)was 0.478(0.303-0.753),P value was 0.001;the results of MR-Egger,weighted median and weighted model were similar to those of IVW.The Cochran's Q values of IVW and MR-Egger regression were 143.733(P=0.893)and 143.303(P =0.888),respectively,suggesting that there was no heterogeneity between SNPs.Conclusion:Vitamin D is one of the protective factors of hyperemesis gravidarum in pregnancy.
Hyperemesis gravidarum in pregnancyVitamin DMendelian randomization study
万方数据
维普
