A case of Castleman's disease of the retroperitoneum with strange-shaped cells
Objective:To investigate the clinical features,pathological features and differential diagnosis of Castleman's disease of the retroperitoneum with strange-shaped cells,so as to reduce misdiagnosis.Methods:The clinical data of 1 case of Castleman's disease of the retroperitoneum with strange-shaped cells admitted to our hospital were retrospectively analyzed and the literature was reviewed.Results:The pa-tient came to the hospital with abdominal distension and discomfort for more than half a year.CT examination showed that a large retroperitoneal mass,and retroperitoneal tumor resection was considered for liposarcoma.Postoperative pathological examination showed that the number of lymphoid follicles increased,the mantle ar-ea widened,germinal center atrophy,a large number of plasma cells and a few lymphocytes between follicles in the background could be seen scattered strange-shape large cells.Immunohistochemical staining showed that CD3,CD5,CD38,CD20 and CD21 were all(+),and CyClinD1(-),Kappa and Lambda were all(+).The patient was diagnosed as Castleman's disease of the retroperitoneum,and was discharged from hospital with recovered well after surgery.After 9 months of follow-up,no obvious signs of recurrence were found.Conclusion:Castleman's disease with strange-shaped cells is rare,and the lack of understanding of strange-shaped cells can easily be misdiagnosed as malignant tumors,leading to overtreatment.The signs and imaging examinations are lack of specificity.Timely histopathological examination is the key to avoid misdiagnosis.
万方数据
维普
