Objective:To investigate the relationship between the proportion of CD19+CD27+IgD+B cells in pe-ripheral blood and disease activity in patients with thyroid-associated ophthalmopathy (TAO).Methods:Flow cytome-try was used to detect the proportion of CD19+CD27+IgD+B cells in TAO patients and healthy control groups.The difference in the proportion of CD19+CD27+IgD+B cells between TAO patients and healthy control groups was ana-lyzed.The correlation between the proportion of CD19+CD27+IgD+B cells and activity was also analyzed.Results:The proportion of CD19+CD27+IgD+B cells in TAO patients was significantly lower than that in healthy controls (P＜0.05).The proportion of CD19+CD27+IgD+B cells in active TAO patients was significantly lower than in inac-tive TAO patients.The proportion of CD19+CD27+IgD+B cells was significantly negatively correlated with the CAS score of TAO patients (r=-0.7128,P＜0.001).Conclusion:The proportion of CD19+CD27+IgD+B cells in TAO patients is decreased,which is negatively correlated with disease activity.
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