首页|CD19+CD27+IgD+B细胞与甲状腺相关性眼病患者疾病活动度相关性研究

CD19+CD27+IgD+B细胞与甲状腺相关性眼病患者疾病活动度相关性研究

The correlational research on CD19+CD27+IgD+B cells and disease activity in patients with thyroid-associated ophthalmopathy

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目的:探讨甲状腺相关性眼病(thyroid-associated ophthalmopathy,TAO)患者外周血CD19+CD27+IgD+B细胞比例变化与病情活动度的关系.方法:采用流式细胞术检测TAO患者和健康对照组CD19+CD27+IgD+B细胞比例,分析TAO患者CD19+CD27+IgD+B细胞比例与健康对照组的差异,并分析CD19+CD27+IgD+B细胞比例与TAO疾病活动度之间的相关性.结果:TAO患者CD19+CD27+IgD+B细胞比例明显低于健康对照(P<0.05);活动性TAO患者CD19+CD27+IgD+B细胞比例细胞显著低于非活动性TAO患者;CD19+CD27+IgD+B细胞比例与TAO患者CAS评分呈显著负相关(r=-0.7128,P<0.001).结论:TAO患者CD19+CD27+IgD+B细胞比例降低,与疾病活动度呈负相关.
Objective:To investigate the relationship between the proportion of CD19+CD27+IgD+B cells in pe-ripheral blood and disease activity in patients with thyroid-associated ophthalmopathy (TAO).Methods:Flow cytome-try was used to detect the proportion of CD19+CD27+IgD+B cells in TAO patients and healthy control groups.The difference in the proportion of CD19+CD27+IgD+B cells between TAO patients and healthy control groups was ana-lyzed.The correlation between the proportion of CD19+CD27+IgD+B cells and activity was also analyzed.Results:The proportion of CD19+CD27+IgD+B cells in TAO patients was significantly lower than that in healthy controls (P＜0.05).The proportion of CD19+CD27+IgD+B cells in active TAO patients was significantly lower than in inac-tive TAO patients.The proportion of CD19+CD27+IgD+B cells was significantly negatively correlated with the CAS score of TAO patients (r=-0.7128,P＜0.001).Conclusion:The proportion of CD19+CD27+IgD+B cells in TAO patients is decreased,which is negatively correlated with disease activity.

Thyroid-associated ophthalmopathyDisease activityCD19+CD27+IgD+B cellsFlow cytometry

冯月兰、刘志英、王媛媛、张伟

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包头医学院第一附属医院,内蒙古 包头014010

甲状腺相关性眼病 疾病活动度 CD19+CD27+IgD+B细胞 流式细胞术

内蒙古自治区自然科学基金项目内蒙古自治区自然科学基金项目内蒙古自治区自然科学基金项目包头医学院科学研究基金项目包头医学院科学研究基金项目包头医学院青年科技计划项目

2021MS080472021MS080512023LHMS08018BYJJ-XG202004BYJJ-QM201926BYJJ-QNGG2022048

2024

10.16833/j.cnki.jbmc.2024.04.006

包头医学院学报
内蒙古科技大学包头医学院

包头医学院学报

影响因子：0.543
ISSN：1006-740X
年,卷(期)：2024.40(4)
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