Correlation between serum metrnl level and glucose,lipid metabolism and liver function in type 2 diabetes patients with nonalcoholic fatty liver disease
Objective:To investigate the correlation between the level of serum adipokines Metrnl and the metabo-lism of glucose,lipid and liver function in type 2 diabetes mellitus(T2DM)patients with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 160 study subjects who were hospitalized and underwent physical examinations in the geriatric department of the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science and Technology from January 2021 to December 2022 were selected.They were divided into a simple T2DM group(n =57 cases),a T2DMcombined with NAFLD group(n=38 cases),and a control group(65 cases)based on whether they met the diagnostic criteria for NAFLD and T2DM.The anthropometric parameters were recorded,and fasting blood glu-cose(FBG),fasting insulin(FINS),glutamic transaminase(AST),glutamic transaminase(ALT),γ-Glutamyl transpeptidase(GGT),albumin,total cholesterol(TC),total cholesterol(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),glycosylated hemoglobin Ah(HbA1 C),uric acid(UA),and fat factor Metrnl were compared between groups.The correlation between Metrnl,glucose and lipid metabo-lism,and liver function in patients with T2DMcombined with NAFLD were observed.Results:The levels of Metrnl and albumin in the pure T2DMgroup were lower than those in the control group(P<0.05),while the levels of FBG,TC,and HbA1c in the pure T2DMgroup were higher than those in the control group(P<0.05);The levels of Metrnl and albumin in the T2DMcombined with NAFLD group were lower than those in the control group(P<0.05),while the levels of AST,ALT,GGT,TG,LDL-C,FBG,and HbA1c in the T2DM combined with NAFLD group were higher than those in the control group(P<0.05);The Metrnl levels in the T2DM combined with NAFLD group were lower than those in the T2DMgroup,while the AST and GGT levels in the T2DMcombined with NAFLD group were higher than those in the T2DMgroup(P<0.05).Correlation analysis showed that Metrnl was negatively correlated with GGT(r=-0.288),FBG(r=-0.714),HbA1c(r=-0.513),and TG(r=-0.2)(P<0.05).The results of multi-ple logistic analysis showed that Metrnl,FBG,LDL-C,and albumin were all independent influencing factors for the occurrence of T2DMcombined with NAFLD(P<0.05).Conclusion:The levels of Metrnl in NAFLD patients are low-er than those in the control group,and there is a negative correlation between Metrnl levels and FBG,HbA1c,TG,GGT levels.The decrease in Metrnl levels is an independent risk factor for the occurrence of T2DM combined with NAFLD,suggesting that Metrnl is a protective factor that may improve glucose and lipid metabolism disorders in T2DMcombined with NAFLD patients and provide new ideas for disease treatment.
Type 2 diabetesNonalcoholic fatty liver diseaseMetrnlGlycolipid metabolismLiver function