Relationship between serum MCP-1,NLRP3 inflammasome expression and intestinal flora in elderly patients with hypertension
Objective:To study the relationship between serum monocyte chemoattractant protein-1(MCP-1)and NOD-like receptor protein 3(NLRP3)inflammasome expression and intestinal flora in elderly hypertensive patients.Method:A total of 84 elderly patients with essential hypertension admitted to our hospital from January 2019 to January 2021 were selected.According to the 2018 Euro-pean Hypertension Guidelines,all patients with hypertension were divided into extremely high-risk group(28 cases),high-risk group(38 cases)and low-medium-risk group(18 cases).The in-testinal flora and serum levels of MCP-1 and NLRP3 inflammasome were detected.Results:There were significant differences in blood pressure,serum creatinine and clinical complications among the three groups(P＜0.05),and there were no significant differences in the other indicators of the pa-tients(P＞0.05).The levels of intestinal bifidobacteria and lactobacilli in the subjects of the ex-tremely high-risk group were lower than those in the high-risk group and low-medium-risk group(P＜0.05);and the levels of Bacteroides,Enterococcus and Escherichia coli in the extremely high-risk group were higher than those in the the high-risk group and the low-medium-risk group were high(P＜0.05);while the levels of intestinal bifidobacteria,Lactobacillus,Bacteroides,en-terococci and Escherichia coli were similar in the high-risk and low-medium-risk group(P＞0.05).The serum levels of MCP-1 and NLRP-3 in the extremely high-risk group were higher than in the high-risk group and the low-medium-risk group(P＜0.05),and the serum levels of MCP-1 and NLRP-3 in the high-risk group were higher than those in the low-medium-risk group(P＜0.05).Pearson correlation analysis showed that MCP-1 level in patients was negatively correla-ted with intestinal bifidobacteria and Lactobacillus content in patients with hypertension,and was posi-tively correlated with Bacteroides,Enterococcus and Escherichia coli(P＜0.05).The level of NL-RP3 was negatively correlated with the content of intestinal bifidobacteria and Lactobacillus in patients with hypertension,and positively correlated with Bacteroides,Enterococcus and Escherichia coli.Con-clusion:The intestinal flora of elderly hypertensive patients is out of balance,and the serum levels of MCP-1 and NLRP-3 are correlated with the intestinal flora.
HypertensionMonocyte chemoattractant protein-1NOD-like receptor protein 3Intestinal flora
NETL
NSTL
万方数据
维普
