Mechanism of Mongolian medicine Sendeng-9 decoction in the treatment of brucellosis based on network pharmacology based on network pharmacology
Objective:To explore the mechanism of Mongolian medicine Sendeng-9 Decoction(BrucellosisⅡ)in the treatment of brucellosis by network pharmacology.Methods:The BATMAN-TCM database was used to analyze the active components and potential targets of Mongolian medicine Sendeng-9 decoction.Brucellosis-related targets were screened through Genecards,OMIM,and DisGeNET databases.The Venn diagram was constructed to obtain the intersection target of disease and the intersection target of Mongolian medicine Sendeng-9 decoction in the treatment of brucellosis.The net-work diagram of"drug-component-disease-target"relationship was drawn by Cytoscape software.The protein-protein interaction(PPI)network of'active ingredient-disease'common targets was constructed by STRING database.Gene on-tology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)pathway enrichment analysis of key targets were per-formed using the David database.Results:There were 182 active components of Mongolian medicine Sendeng-9 Decoc-tion,which acted on 1306 targets.There were 620 brucellosis targets and 152 drug-disease intersection targets.The main active ingredients of Mongolian medicine Sendeng-9 Decoction in the treatment of brucellosis were lauric acid,myristic acid,linoleic acid,jasmonone,lupinone,geranylacetone,oxysophocarpine,3-nonen-2-one,etc.The core targets for the treatment of brucellosis were IL-6,IL-1β,INS,TNF,PTGS2,JUN,TP53,IGF1,CCL2,HIF1A.A total of 1064 GO entries were obtained,including 834 BP entries,107 CC entries,and 123 MF entries.There were 162 KEGG signaling pathways,mainly focusing on HIF-1 signaling pathway,TNF signaling pathway,MAPK signaling pathway,FoxO signa-ling pathway,IL-17 signaling pathway and so on.Conclusion:Through the method of network pharmacology,this study preliminarily discusses the anti-inflammatory and disease-resistant pathogenic microorganisms of the effective components of Mongolian medicine Senden-9 decoction,which provides a theoretical basis for the treatment of brucellosis,and further study of the mechanism of action and clinical application of this prescription.
Network pharmacologyMongolian medicine Sendeng-9 decoctionBrucellosisSignaling pathwayMechanism of action
NETL
NSTL
万方数据
维普
