The mechanism of ginsenoside Rb1 in the treatment of Parkinson's disease based on network pharmacology
Objective:To explore the mechanism of ginsenoside Rb1 in the treatment of Parkinson's disease by u-sing network pharmacology technology,and to provide scientific theoretical basis for the clinical rational application of ginsenoside Rb1.Methods:The targets of ginsenoside Rb1 were predicted in SwissTargetPrediction,SEA and Super-Pred databases.The related targets of Parkinson's disease were obtained in the GeneCards and Omim databases using the keyword'Parkinson Disease'.The ginsenoside Rb1 and the target of Parkinson's disease were mapped to each other,and the Veen diagram was made to obtain the intersection gene.Then,Cytoscape 3.8.2 software was used to construct the'drug-target'network;the 21 common drug targets related to Parkinson's disease in the Venn diagram were imported into the String(https://string-db.org/)database for protein-protein interaction prediction,so as to predict the core tar-gets.The core targets of ginsenoside Rb1 in the treatment of Parkinson's disease were imported into the DAVID database to obtain GO analysis results and KEGG enrichment results.AutoDock Vina was used to perform molecular docking be-tween ginsenoside Rb1 and key targets to verify their interaction activity.Results:There were four core targets of gin-senoside Rb1 in the treatment of Parkinson's disease,namely BCL2L1,VEGFA,FGF2,KDR,with 28 related path-ways.Combined with the biological characteristics of ginsenoside Rb1,it was found that ginsenoside Rb1 treatment of Parkinson's disease mght be involved in the biological regulation process through the PI3K/Akt signaling pathway,and this regulation process was closely related to the mechanism of apoptosis in cell bioengineering.Through the molecular docking verification of the key target and ginsenoside Rb1,the target interaction was highly combined.Conclusion:The mechanism of ginsenoside Rb1 in the treatment of PD may play a role by reducing the biological process of apoptosis.The related pathways affected are PI3K/Akt signaling pathway,MAPK signaling pathway,Notch signaling pathway,and BCL2L1,VEGFA,FGF2,KDR and other targets.
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