Effects of different doses of sufentanil on postoperative cognitive function in aged rats with perioperative cognitive dysfunction
Objective:To evaluate the effects of different doses of sufentanil on postoperative cognitive impairment in aged rats with perioperative cognitive dysfunction.Methods:Sixty aged(18-22 months)rats were randomly divided into 6 groups using a random number table method:control group,PND model group(splenectomy),sufentanil group A(splenectomy+sufentanil 1 μg·kg-1),sufentanil group B(splenectomy+sufentanil 2 μg·kg-1),sufentanil group C(splenectomy+sufentanil 4 μg·kg-1),sufentanil group D(splenectomy+sufentanil8 μg·kg-1),with 10 rats in each group.First,the Morris water maze was used to conduct space acquisition experiments for 5 consecutive days of all the groups.On the 6th day,model construction and/or preoperative sufentanil intraperitoneal intervention were per-formed on all the other groups of aged rats except for the control group.All aged rats were tested for spatial memory on the 1,3 and 7 days after surgery.Results:Space-acquired experiments made the memory of platform position in aged rats gradually deepen with time(P＜0.05),and rats gained effective memory of platform position,there was no differ-ence between the groups.The reference memory test results showed that the difference in spatial memory between the control group and each of the other groups was statistically significant(P＜0.05).There was significant difference in spatial memory ability between the model group and the sufentanil B group,the sufentanil C group and the sufentanil D group(P＜0.05).In addition to the control group,the spatial memory ability of the sufentanil C group was significantly different from that of the other groups(P＜0.05).Conclusion:Different doses of sufentanil have different effects on postoperative spatial memory in elderly rats,while intraperitoneal injection of 4 μg·kg-1 sufentanil can significantly improve the spatial memory ability and postoperative cognitive function of splenectomy PND model rats.
万方数据
维普
