Meta-analysis of integrated traditional Chinese and Western medicine therapy with Biling Weitong Granules in the treatment of Helicobacter pylori infection
Objective:To investigate the efficacy and safety of the integrated traditional Chinese and Western medicine therapy with Biling Weitong Granules in combination with conventional Western medicine quadruple or triple therapy compared to traditional Western medicine therapy for eradicating Helicobacter pylori(H.pylori).Methods:PubMed,Embase,Cochrane Library,China National Knowledge Infrastructure,Wanfang Database and Sinomed were searched,and the randomized con-trolled studies about the application of Biling Weitong Granule for eradicating H.pylori eradication were collected.The retrieval period was from the establishment of the database to November 2022.Data ex-traction and literature quality evaluation were performed on the retrieved literature according to the Co-chrane system evaluation method.Meta-analysis was performed using RevMan 5.4 software.Results:A total of 4 articles and 506 patients were included.The results of Meta-analysis showed that the eradication rate of H.pylori in the experimental group was higher than that in the control group(OR=4.18,95%CI:2.57-6.79,I2=0%,P＜0.00001).In terms of safety,the incidence of ad-verse reactions in the experimental group was lower than that in the control group(OR=0.30,95%CI:0.10-0.85,I2=0%,P=0.02).Conclusion:The integrated traditional and Western medicine treatment regimen with Biling Weitong Granules is significantly better than the western medicine quad-ruple and triple therapy in terms of efficacy and safety.
Helicobacter pyloriBiling Weitong GranulesIntegrated traditional Chinese and western medicineEradicate treatment
万方数据
维普
