Clinical significance of coagulation index combined with tumor marker detection in colon cancer
Objective:To detect the expression of coagulation function and tumor markers in patients with colon cancer,and to analyze its relationship with tumor development.Methods:A total of 50 patients with colon cancer diag-nosed in the Digestive Minimally Invasive Center of the Second Affiliated Hospital of Baotou Medical College from Janu-ary 2021 to June 2022 were selected as the observation group,and 50 serum samples with normal results were selected as the control group.The serum tumor markers such as carcinoembryonic antigen(CEA)and carbohydrate antigen-199(CA-199)and coagulation function related indicators such as prothrombin time(PT)and activated partial prothrombin time(APTT)were detected in the two groups,and the differences in the expression of different indicators between groups and within groups were analyzed.Results:Compared with control group,APTT and PT in observation group were significantly decreased(P＜0.05),CEA and CA-199 were significantly increased(P＜0.05).In the observation group,compared with different clinical stages(Ⅰ-ⅡandⅢ-Ⅳ),the time of PT and APTT inⅠ-Ⅱwas longer than that inⅢ-Ⅳ(P＜0.05),and the values of CEA and CA-199 were lower(P＜0.05);compared with different differentiation degrees(high-middle differentiation and low differentiation),the time of PT and APTT in high-middle differentiation was longer than that in low differentiation(P＜0.05),and the values of CEA and CA-199 were de-creased(P＜0.05).Conclusion:In patients with colon cancer,tumor markers CEA and CA-199 and coagulation-related indicators APTT and PT are abnormally expressed,and combined detection can provide a basis for clinical diag-nosis.At the same time,combined detection can predict the stage and differentiation of colon tumors.
Carbohydrate antigen CA199Carcinoembryonic antigenProthrombin timeActivated partial throm-boplastin timeColon cancer
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维普
