Early expression of LCN2 in serum and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage
Objective:To analyze the early expression of lipocalin-2(LCN2)in serum and cerebrospinal fluid of patients with aneurysmal subarachnoid hemorrhage(aSAH),and to explore its correlation with the severity of early brain injury(EBI).Methods:Patients who were diagnosed with aSAH and onset within 3 days in the Department of Neurolo-gy of Baotou Central Hospital from 2020 to 2022 were selected as the aSAH group,other patients with the matched age and gender during the same period were selected as the control group.The levels of serum and cerebrospinal fluid LCN2 and cerebrospinal fluid LCN2 levels at different time points were determined by ELISA.The severity of brain injury was assessed by Hunt-Hess scale and divided into three groups:group I:Hunt-Hess grade Ⅰ,group Ⅱ:Hunt-Hess grade Ⅱ and group Ⅲ:Hunt-Hess grade Ⅲ-Ⅴ.To analyze the correlation between the severity of EBI,the levels of serum and cerebrospinal fluid LCN2.Results:A total of 47 patients enrolled.The levels of serum and the cerebrospinal fluid LCN2 in the aSAH group were both higher than those in the control group,and the differences were statistically sig-nificant(P<0.001).The levels of serum and the cerebrospinal fluid LCN2 in the group Ⅱ were both higher than those in the group Ⅰ,and the differences were statistically significant(P<0.05).The levels of serum and cerebrospinal fluid LCN2 in the group Ⅲ were both higher than those in the group Ⅱ,and the differences were statistically significant(P<0.05).Meanwhile,Hunt-Hess grade was positively correlated with levels of serum LCN2 and cerebrospinal fluid LCN2,and the difference was statistically significant(rs>0,P<0.05).ROC curve shows that the area under ROC curve of the serum LCN2 was 0.876(the specificity was 100.00％,the sensitivity was 61.70％),and the best predic-tive diagnostic limit was 45.68 ng/mL.The area under ROC curve of the cerebrospinal fluid LCN2 was 0.914(the spe-cificity was76.60％,the sensitivity was100.00％),and the best predictive diagnostic limit was 15.08 ng/mL.Con-clusions:The LCN2 level of the body fluid in aSAH patients increased significantly in the early stage,which is closely related to EBI and may be involved with the pathogenesis of EBI.
万方数据
维普
