Latent class growth model-based study of medication adherence trajectories and its influence factors in elderly patients with Parkinson's disease
王曙光 1丁时磊 1何彩玉 1汪玉玲 1江玉琨 1程璐 2姚瑞萍 1肖勇1
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作者信息
1. 滁州城市职业学院医学系,安徽 滁州 239000
2. 滁州第一人民医院药学部
折叠
摘要
目的:利用潜类别增长模型(latent class growth model,LCGM)分析老年帕金森病患者用药依从性轨迹,并验证其影响因素.方法:对124 例原发性老年帕金森病患者进行 12 个月随访调查,调查工具包括一般资料调查表和Morisky用药依从性量表.通过潜类别增长模型识别患者用药依从性轨迹,采用有序多分类Logistic回归分析用药依从性轨迹的影响因素.结果:老年帕金森病患者用药依从性分为"高-持续型""中-下降型"和"低-下降型"3 种类型,且该3 种类型文化程度、工作状态、用药种类、智力状态比较,差异有统计学意义(P<0.05).有序多分类Logistic回归显示,工作状态、用药种类、智力状态是患者用药依从性轨迹的影响因素(P<0.05).结论:老年帕金森患者用药依从性分为3 种轨迹,工作状态、用药种类和智力状态是用药依从性轨迹类别的影响因素.
Abstract
Objective:To study the medication adherence trajectories and its influence factors in elderly pa-tients with Parkinson's disease with latent class growth model(LCGM).Methods:A 12-month follow-up survey was conducted in 124 elderly patients with primary Parkinson's disease,the general information questionnaire and Morisky medication adherence scale were used as survey tools.The LCGM was used to identify the trajectory catego-ry of patients'medication adherence,and the factors that affecting the trajectory category were analyzed by multi-level ordered logistic model.Results:The medication adherence type of elderly patients with Parkinson's disease were divided into the high-persistence type,medium-descending type and low-descending type.The differ-ences was statistically significant in educational level,working status,medication types and intellectual level among the high-persistence group,medium-descending group and low-descending group(P<0.05).Multilevel or-dered logistic analysis results showed that working status,medication type and intelligence level were the influencing factors that affecting the medication adherence trajectory of elderly patients with Parkinson's disease(P<0.05).Conclusion:The medication adherence trajectory can be divided into three categories,working status,medication type and intelligence level are the influencing factors that affecting the medication adherence trajectory of elderly pa-tients with Parkinson's disease.
关键词
帕金森病/老年人/用药依从性/轨迹/潜类别增长模型
Key words
Parkinson's disease/Elderly/Medication adherence/Trajectory/Latent class growth model
维普
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