首页|基于潜类别增长模型分析老年帕金森病患者用药依从性轨迹及影响因素

基于潜类别增长模型分析老年帕金森病患者用药依从性轨迹及影响因素

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目的:利用潜类别增长模型(latent class growth model,LCGM)分析老年帕金森病患者用药依从性轨迹,并验证其影响因素.方法:对124 例原发性老年帕金森病患者进行 12 个月随访调查,调查工具包括一般资料调查表和Morisky用药依从性量表.通过潜类别增长模型识别患者用药依从性轨迹,采用有序多分类Logistic回归分析用药依从性轨迹的影响因素.结果:老年帕金森病患者用药依从性分为"高-持续型""中-下降型"和"低-下降型"3 种类型,且该3 种类型文化程度、工作状态、用药种类、智力状态比较,差异有统计学意义(P<0.05).有序多分类Logistic回归显示,工作状态、用药种类、智力状态是患者用药依从性轨迹的影响因素(P<0.05).结论:老年帕金森患者用药依从性分为3 种轨迹,工作状态、用药种类和智力状态是用药依从性轨迹类别的影响因素.
Latent class growth model-based study of medication adherence trajectories and its influence factors in elderly patients with Parkinson's disease
Objective:To study the medication adherence trajectories and its influence factors in elderly pa-tients with Parkinson's disease with latent class growth model(LCGM).Methods:A 12-month follow-up survey was conducted in 124 elderly patients with primary Parkinson's disease,the general information questionnaire and Morisky medication adherence scale were used as survey tools.The LCGM was used to identify the trajectory catego-ry of patients'medication adherence,and the factors that affecting the trajectory category were analyzed by multi-level ordered logistic model.Results:The medication adherence type of elderly patients with Parkinson's disease were divided into the high-persistence type,medium-descending type and low-descending type.The differ-ences was statistically significant in educational level,working status,medication types and intellectual level among the high-persistence group,medium-descending group and low-descending group(P<0.05).Multilevel or-dered logistic analysis results showed that working status,medication type and intelligence level were the influencing factors that affecting the medication adherence trajectory of elderly patients with Parkinson's disease(P<0.05).Conclusion:The medication adherence trajectory can be divided into three categories,working status,medication type and intelligence level are the influencing factors that affecting the medication adherence trajectory of elderly pa-tients with Parkinson's disease.

Parkinson's diseaseElderlyMedication adherenceTrajectoryLatent class growth model

王曙光、丁时磊、何彩玉、汪玉玲、江玉琨、程璐、姚瑞萍、肖勇

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滁州城市职业学院医学系,安徽 滁州 239000

滁州第一人民医院药学部

帕金森病 老年人 用药依从性 轨迹 潜类别增长模型

滁州城市职业学院科研项目滁州城市职业学院教研项目安徽省教研重点项目药理课程思政教学案例建设项目药理学示范课项目安徽省高等学校科学研究项目

2022zkyb012020jyxm022021jyxm10382021tszjxa1052021tjpzxkfkc082022AH052872

2024

包头医学院学报
内蒙古科技大学包头医学院

包头医学院学报

影响因子:0.543
ISSN:1006-740X
年,卷(期):2024.40(7)