YAP基因SNP rs11225163与大肠癌的关联研究
Association between YAP gene SNP rs11225163 and colorectal cancer
高芳 1卫星如 1李迎泽 2董文杰 1陈雅茹 1王巧巧 1贾彦彬1
作者信息
- 1. 包头医学院,内蒙古 包头014040
- 2. 包头市肿瘤医院
- 折叠
摘要
目的:研究YAP基因单核苷酸多态性(single nucleotide polymorphism,SNP)rs11225163位点与大肠癌发病风险的关系.方法:选取390例大肠癌病例和413例对照组,采用Taqman技术对YAP rs11225163进行基因分型,并用非条件性Logistic回归计算比值比(OR)及其95％置信区(CI)间评估在共显性、显性、隐性、超显性、附加五种遗传模式下rs11225163与大肠癌、直肠癌、结肠癌发病风险的关系.结果:在五种遗传模式下,SNP rs11225163与大肠癌、直肠癌、结肠癌的发病风险没有关联(P>0.05).结论:YAP基因SNP rs11225163可能在大肠癌、直肠癌、结肠癌的发病过程中不起主要作用.
Abstract
Objective:To studythe associationbetweensingle nucleotide polymorphism (SNP)in YAPgene andthe risk of colorectal cancer.Methods:YAP rs11225163 was genotyped by Taqman technique in 390 colorectal cancer cases and 413 controls.The odds ratio (OR)and its 95％ confidence interval(CI)were calculated by unconditional logistic regression to evaluate the relationship between rs11225163 and the risk of colorectal cancer,rectal cancer and colon cancer under five genetic models:co-dominant,dominant,recessive,overdominant and Log-additive.Results:No associations were found between SNP rs11225163 and the risk of colorectal cancer,rectal cancer and colon cancer under 5 genetic models.Conclusion:YAP gene SNP rs11225163 may not play a major role in the development of colorectal cancer,rectal cancer and colon cancer.
关键词
YAP基因/大肠癌/单核苷酸多态性/发病风险/关联研究Key words
YAPgene/Colorectal cancer/Single nucleotide polymorphism/Risk/Association study引用本文复制引用
基金项目
内蒙古自然科学基金(2020LH08004)
内蒙古自然科学基金(2021MS08054)
包头医学院创新团队发展计划项目(bycxtd-06)
包头医学院科学研究基金项目(BYJJ-GDJY202313)
出版年
2024
NETL
NSTL
万方数据