Association between YAP gene SNP rs11225163 and colorectal cancer
Objective:To studythe associationbetweensingle nucleotide polymorphism (SNP)in YAPgene andthe risk of colorectal cancer.Methods:YAP rs11225163 was genotyped by Taqman technique in 390 colorectal cancer cases and 413 controls.The odds ratio (OR)and its 95％ confidence interval(CI)were calculated by unconditional logistic regression to evaluate the relationship between rs11225163 and the risk of colorectal cancer,rectal cancer and colon cancer under five genetic models:co-dominant,dominant,recessive,overdominant and Log-additive.Results:No associations were found between SNP rs11225163 and the risk of colorectal cancer,rectal cancer and colon cancer under 5 genetic models.Conclusion:YAP gene SNP rs11225163 may not play a major role in the development of colorectal cancer,rectal cancer and colon cancer.
YAPgeneColorectal cancerSingle nucleotide polymorphismRiskAssociation study
NETL
NSTL
万方数据
