Relationship between 25-hydroxyvitamin D and motor symptoms of Parkinson's disease
Objective:To investigate the relationship between 25-hydroxyvitamin D and motor symptoms of Parkinson's disease (PD).Methods:A total of 105 PD patients admitted in our hospital from January 2019 to December 2021 were selected as the PD group.The total scores of tremor,pos-tural instability/gait difficulty (PIGD)were calculated according to MDS-UPDRS Ⅱ～Ⅲ item.The PD patients were divided into the tremor-dominant (TD)type (n=33 ),postural instability/gait dif-ficulty (PIGD)type (n=48),and middle type (n=24).During the same period,50 elderly health checkups were used as a control group,25-hydroxyvitamin D,ferritin,albumin,serum uric acid of the two groups of patients were detected.Results:The incidence of vitamin D deficiency in the PD group was 82.90％,which was higher than that in healthy control group 68.00％(34/50),and the difference was statistically significant (P<0.05 ).The average level of 25-hydroxyvitamin D in the PD group was 15.16±5.13 ng/L,lower than that of 17.53±4.88 ng/L in control group,and the difference was statistically significant (P<0.05 ).The level of 25-hydroxyvitamin D in the PIGD type (13.22±4.82 ng/L)was lower than that in the TD type (17.11±4.85 ng/L)and middle type (16.37±4.90 ng/L)PD patients,and the differences were statistically significant (P<0.017 ). There was a strong negative correlation between 25-hydroxyvitamin D level and MDS-UPDRS Ⅲ score (rs=-0.645).Unitary linear regression analysis of 25-hydroxyvitamin D level and MDS-UPDRS Ⅲ score on one-way linear regression analysis (B=-2.556,P=0.000).Conclusion:The incidence of vitamin D deficiency is high in PD patients,and the vitamin D level is lower in the PIGD type PD patients.Vitamin D level is correlated with motor typing and severity of motor symptoms in PD patients.
Parkinson's disease25 hydroxyvitamin DClinical motor typing
NETL
NSTL
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