GPIa C807T和G873A基因多态性对血小板聚集抑制率的影响
Effect of GPIa C807T and G873A gene polymorphisms on platelet aggregation inhibition rate
焦瑞宝 1陈迎春 1江世芳 1周佳丽 1张盛 1陈继中1
作者信息
- 1. 皖南医学院附属铜陵市人民医院临床检验中心,安徽 铜陵244000
- 折叠
摘要
目的:探讨GPIa C807T和G873A基因多态性对血小板聚集抑制率的影响,为临床个体化抗血小板聚集治疗提供实验数据支持.方法:收集正在使用阿司匹林抗血小板聚集治疗的住院患者80例,采用血栓弹力图仪检测血小板聚集抑制率,根据聚集抑制率检测结果分为阿司匹林抵抗(aspirin resistance,AR)组(共10例)和阿司匹林敏感(aspirin sensitivity,AS)组(共70例),分析GPIa C807 T、G873 A基因型及其等位基因在两组分布状况以及两者患者临床资料与实验检测指标关系.结果:AR组807T、873G等位基因高于AS组(x2=4.039、4.354,P=0.044、0.037);AR组高血压病史患病率、卒中史高于AS组(x2=4.612、4.737,P=0.032、0.030);AR组血浆D-二聚体(D-D)、血清甘油三酯(TG)高于AS组(t=2.499、2.276,P=0.016、0.033),而AR组血小板聚集抑制率、血清葡萄糖低于AS组(t=15.352、3.076,P<0.001、0.005).结论:GPIa C807T和G873A基因多态性与AR存在相关性,建议联合检测两基因位点的多态性并结合血小板聚集抑制率,共同指导临床个体化抗血小板聚集治疗.
Abstract
Objective:To explore the effect of GPIa C807T and G873A gene polymorphisms on platelet aggregation inhibition rate,aiming to provide experimental data for clinical individualized anti-platelet aggregation therapy.Methods:A total of 80 inpatients receiving antiplatelet treatment with as-pirin were collected and divided into two groups according to the inhibition rate of platelet aggregation detected by thromboelastography.10 patients were divided into the aspirin resistance (AR)group and 70 patients into the aspirin sensitive (AS)group.The genotypes of GPIa C807T,G873A and their al-lele distribution in the two groups were analyzed,and the relationship between clinical data and experi-mental indicators of the two groups were also analyzed.Results:The 807T and 873G alleles in the AR group were higher than those in the AS group (x2=4.039,4.354,P=0.044,0.037).The preva-lence of hypertension and stroke history in the AR group was higher than that in the AS group (x2=4.612,4.737,P=0.032,0.030).Plasma D-dimer (D-D)and serum triglyceride (TG)in the AR group were higher than those in the AS group (t=2.499,2.276,P=0.016,0.033),while platelet aggregation inhibition rate (IPA)and serum glucose (GLU)in the AR group were lower than those in the AS group (t=15.352,3.076,P<0.001,0.005 ).Conclusion:GPIa C807T and G873A gene polymorphism were correlated with aspirin resistance.Joint detection of the two gene loci polymorphisms and platelet aggregation inhibition rate was recommended to jointly guide the clinical in-dividualized antiplatelet aggregation therapy.
关键词
血小板膜糖蛋白/阿司匹林抵抗/基因突变/相关性/抗血小板聚集Key words
Platelet membrane glycoprotein/Aspirin resistance/Genetic mutation/Antiplatelet aggregation/Individualization引用本文复制引用
基金项目
铜陵市科技计划项目(20190203034)
安徽省教育厅2021年提质培优行动计划项目()
皖南医学院2022年校教学医院科研专项立项(JXYY202209)
出版年
2024
NETL
NSTL
万方数据