Effects of Helicobacter pylori infection on LncRNA,NO and corticosterone in hypertensive patients and rats
Objective:To analyze the effects of Helicobacter pylori on blood pressure,carotid athero-sclerosis,long non-coding RNA (LncRNA)MALAT1,nitric oxide (NO),corticosterone and new cardi-ovascular and cerebrovascular diseases.Methods:The patients with both hypertension and Helicobacter pylori infection were divided into experimental group and control group.296 cases each.The control group was treated with antihypertensive and lipid-lowering treatment,and the experimental group was treated with anti-Helicobacter pylori drugs on this basis.Then the changes of blood pressure,blood lipid level,carotid intima thickness and heart rate were compared between the two groups.After 2 years of follow-up,the proportion of new cardiocerebral artery occlusion was observed.Thirty-two 6-week-old male rats were divided into spontaneously hypertensive rats (SHR)group A and group B,Wistar-Kyoto (WKY)rats group C and group D,with 8 rats in each group.Rats in group A and group C were given Helicobacter pylori gavage,and rats in group B and group D were given 0.9％ NaCl gavage.After 14 weeks,blood and gastric tissue were taken for detection.Results:(1 )Helicobacter pylori affected blood pressure,so that the blood pressure of SHR and WKY rats were significantly increased;the degree of hy-pertension in SHR was more obvious (P<0.05).(2)The increase of Helicobacter pylori value affected the levels of LncRNA MALAT1,NO and corticosterone (P<0.05).(3)The proportion of new heart and cerebral artery insufficiency or even occlusion after the decrease of Helicobacter pylori value was less than that of the control group (P<0.05).Conclusion:(1)The content of Helicobacter pylori is positively cor-related with the increase of blood pressure,LncRNA MALAT1 and corticosterone,and negatively correla-ted with NO.(2)After the treatment of Helicobacter pylori,it can reduce the degree of blood pressure level and the proportion of coronary cerebral artery occlusion.
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