Clinical observation of total glucosides of paeony combined with bicyclol in the treatment of mild autoimmune hepatitis
Objective:To observe the clinical effect and safety of total glucoside of paeony com-bined with bicyclol in the treatment of mild autoimmnue hepatitis.Methods:A total of 56 patients with mild AIH admitted from April 2020 to April 2023 were randomly divided into treatment group and con-trol group,with 28 patients in each group.The treatment group was given total glucosides of paeony (0.6 g/time,3 times/d)combined with bicyclol (50 mg/time,3 times/d)oral treatment,while the control group was only given bicyclol (50 mg/time,3 times/d)oral treatment.The liver inflammation indexes,immunological related indexes and liver fibrosis indexes of the two groups were measured at baseline,12 weeks and 24 weeks of treatment,and the drug-related adverse reactions were recorded. Results:After 24 weeks,the total effective rates of the treatment group and the control group were 89.29％ and 60.71％,respectively,and the difference was statistically significant (P=0.037). There were significant differences in ALT,AST,CD4+T(％),CD8+T(％),total globulin and IgG levels between the two groups (P<0.001 ),but there was no significant difference in ALP and liver stiffness measurement (LSM)between the two groups (P=0.72).Compared with the control group,the levels of ALT,AST,CD8+T(％),total globulin and IgG in the treatment group decreased,and the level of CD4+T(％)increased after 24 weeks.Compared with the baseline,the LSMvalues of the two groups decreased after 24 weeks.There was no significant difference in the incidence of adverse re-actions between the two groups (P=1 .0).Conclusion:Total glucosides of paeony combined with bi-cyclol can better improve the level of liver inflammation in patients with mild AIH,regulate the im-mune status of the body,control the progression of liver fibrosis and do not increase the incidence of adverse drug reactions.
Total glucoside ofpaeonyBicyclolAutoimmune hepatitisMild case
NETL
NSTL
万方数据
