Analysis of correlation between glycosylated hemoglobin control level and gonadal hormone in middle-aged and elderly male patients with type 2 diabetes mellitus
Objective:To investigate the effect of glycated hemoglobin control level on gonadal hormone,body mass index,blood lipid and visceral fat area in middle-aged and elderly male patients with type 2 diabetes mellitus,and to analyze the related factors affecting testosterone.Methods:A to-tal of 90 middle-aged and elderly male patients with type 2 diabetes mellitus were selected and divid-ed into good blood glucose control group (30 patients,glycosylated hemoglobin<7％),poor blood glucose control group (30 patients,glycosylated hemoglobin 7％～9％)and bad blood glucose control group (30 patients,glycosylated hemoglobin>9％),the age,body mass index,blood lipid,visceral fat area and gonadal hormone of the patients were collected,and the data of the three groups were sta-tistically analyzed.According to testosterone greater than the median (≤4.08 ng/mL)and less than or equa to the median (<4.08 ng/mL),they were divided into two groups,and the body mass index,visceral fat area,glycosylated hemoglobin,blood lipids and other data between the two groups were statistically analyzed.Results:The level of glycosylated hemoglobin was negatively correlated with high density lipoprotein and testosterone (P<0.05),and positively correlated with triglyceride,total cholesterol,low density lipoprotein,body mass index,visceral fat area and estradiol (P<0.05),but not with follicle stimulating hormone,luteinizing hormone and prolactin (P>0.05).Testosterone was negatively correlated with body mass index,visceral fat area,glycosylated hemoglobin,triglyceride,total cholesterol and low density lipoprotein (P<0.05 ),and positively correlated with high density lipoprotein (P<0.05).Logistic regression analysis showed that glycosylated hemoglobin level,viscer-al fat area,body mass index and dyslipidemia were risk factors for testosterone reduction.Conclusion:Good blood glucose control can effectively reduce the decrease of testosterone in men,and can effec-tively promote the body's lipid metabolism;higher testosterone levels also play a positive role in blood glucose and lipid metabolism.Glycosylated hemoglobin,visceral fat area,body mass index,dyslipi-demia are risk factors for testosterone reduction.
Middle-aged and elderly menType 2 diabetes mellitusGlycosylated hemoglobinGonadal hormoneBody mass indexVisceral fat areaBlood lipid
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