首页|胃泌素释放肽前体与神经元特异性烯醇化酶在小细胞肺癌诊疗过程中的价值

胃泌素释放肽前体与神经元特异性烯醇化酶在小细胞肺癌诊疗过程中的价值

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目的:研究在小细胞肺癌诊疗过程中胃泌素释放肽前体(gastrin releasing peptide pre-cursor,Pro-GRP)与神经元特异性烯醇化酶(neuron specific enolase,NSE)的价值.方法:选取蚌埠医学院第一附属医院2020年4月-2021年3月期间在呼吸与危重症医学科住院、且首次确诊的小细胞肺癌(38例)、非小细胞肺癌(65例)及肺良性病变(51例)的患者,收集纳入患者的临床资料,并通过电化学发光法检测ProGRP及NSE的水平,评估临床诊疗价值.结果:小细胞肺癌组血清Pro-GRP和NSE的水平明显高于非小细胞肺癌组(P<0.05)、肺良性病变组(P<0.05).广泛期小细胞肺癌组血清Pro-GRP和NSE的水平均高于局限期小细胞肺癌组(P<0.05).小细胞肺癌患者血清ProGRP水平与性别、年龄、吸烟史无明显相关性(P>0.05);血清NSE水平与性别、年龄史无明显相关性(P>0.05),但与吸烟存在相关性(P<0.05).采用ROC曲线分析明确了血清Pro-GRP和NSE诊断小细胞肺癌的界值分别为65.78 pg/mL、14.84 ng/mL;血清Pro-GRP诊断小细胞肺癌的敏感度、特异度、约登指数分别为84.21%、96.1%、0.803.NSE的敏感度、特异度、约登指数分别为68.4%、96.1%、0.645.2个周期规范方案化疗后,小细胞肺癌患者化疗后血清Pro-GRP和NSE的水平较化疗前明显降低(P<0.05).结论:血清Pro-GRP和NSE可作为辅助小细胞肺癌诊断和疗效评价的肿瘤标志物.
Value of pro-gastrin-releasing peptide and neuron-specific enolase in the diagnosis and treatment of small cell lung cancer
Objective:To investigate the value of pro-gastrin-releasing peptide(Pro-GRP)and neuron-specific enolase (NSE)in the diagnosis and treatment of small cell lung cancer.Methods:Patients who were hospitalized in the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Bengbu Medical College from April 2020 to March 2021 and were first diagnosed with small cell lung cancer (38 patients),non-small cell lung cancer (65 patients)and benign lung disease (51 patients)were included.The clinical general data of the patients were collected and the levels of ProGRP and NSE were detected by electrochemiluminescence to evaluate the clinical diagnosis and treatment value.Results:The levels of serum Pro-GRP and NSE in small cell lung cancer group were significantly higher than those in non-small cell lung cancer group (P<0.05)and benign lung disease group (P<0.05).The levels of serum Pro-GRP and NSE in extensive small cell lung cancer group were higher than those in limited small cell lung cancer group (P<0.05).There was no signifi-cant correlation between serum ProGRP level and gender,age and smoking history in patients with small cell lung cancer (P>0.05).There was no significant correlation between serum NSE level and gender and age history (P>0.05),but there was a correlation with smoking (P<0.05).ROC curve analysis showed that the cut-off values of serum Pro-GRP and NSE in the diagnosis of small cell lung cancer were 65.78 pg/mL and 14.84 ng/mL,respectively;the sensitivity,specificity and Youden index of serum Pro-GRP in the diagnosis of small cell lung cancer were 84.21%,96.1% and 0.803,respectively;the sensitivity,specificity and Youden index of NSE were 68.4%,96.1% and 0.645,respectively.After 2 cycles of standard chemotherapy,the levels of serum Pro-GRP and NSE in patients with small cell lung cancer after chemotherapy were significantly lower than those be-fore chemotherapy (P<0.05).Conclusion:Serum Pro-GRP and NSE can be used as tumor markers for the diagnosis and efficacy evaluation of small cell lung cancer.

Pro-gastrin-releasing peptideSmall cell lung cancerDiagnosis and treatmentNeuron-specific enolase

洪磊、王若楠

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蚌埠医学院第一附属医院呼吸与危重症医学科,安徽 蚌埠233000

蚌埠医学院

胃泌素释放肽前体 小细胞肺癌 诊疗 神经元特异性烯醇化酶

安徽省省级大学生创新创业训练计划项目

S202110367108

2024

包头医学院学报
内蒙古科技大学包头医学院

包头医学院学报

影响因子:0.543
ISSN:1006-740X
年,卷(期):2024.40(8)