Correlation analysis of sIgA in alveolar lavage fluid with serum total IgA and T lymphocyte subsets in patients with chronic obstructive pulmonary disease
Objective:To explore the clinical significance of sIgA in alveolar lavage fluid,serum IgA and blood T lymphocyte subsets in patients with chronic obstructive pulmonary disease,pneumonia and healthy people by comparing their differences.Methods:The inpatients from the Department of Respiratory and Critical Care Medicine of Baotou Cen-tral Hospital and the health personnel from the Health examination Center of Baotou Central Hospital from December 2018 to March 2020 were collected.There were 29 patients with chronic obstructive pulmonary disease combined with pneumonia (COPD-P group),26 patients with simple chronic obstructive pulmonary disease (S-COPD group),27 patients with simple pneumonia (S-P group),and 27 health personnel in the control group (CG group).sIgA and ser-um levels of IgA,CD4+T cells,CD8+T cells,absolute number of T lymphocytes,CD4+T/CD8+T ratio and other da-ta were detected in alveolar lavage fluid.SPSS 20.0 software was used for data analysis.Results:There was no signifi-cant difference in serum IgA,T lymphocyte absolute number and CD4+T cell percentage among the four groups (P>0.05).sIgA level,CD4+T cell/CD8+T cell ratio,and percentage of CD8+T cell were significantly different a-mong the four groups (P<0.05).Conclusion:sIgA content in alveolar lavage fluid was significantly reduced in patients with S-COPD and COPD P,suggesting that the lack of sIgA on the mucosal surface caused mucosal barrier damage. Infection is associated with a lack of sIgA on the mucosal surface,which may be one of the reasons for the increased chance of COPD infection.The level of CD8+T cells in the serum of COPD patients increased,and the imbalance of the ratio of CD4+T cells/CD8+T cells was common in COPD patients,indicating the dysfunction of cellular immunity.In COPD,the ratio of CD4+T/CD8+T cells was used as one of the indicators to predict the disturbance of the internal cell composition of T lymphocyte subsets,which has a suggestive effect.
Chronic obstructive pulmonary diseasePneumoniaAlveolar lavage fluidSecretory immunoglobulin AT lymphocyte subsets
NETL
NSTL
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