Correlation analysis between TSH level and various factors of metabolic syndrome in thyroid nodule population
Objective:To investigate the association between thyroid stimulating hormone(TSH)level and metabol-ic syndrome(MS)in patients with thyroid nodules(TN).Methods:A total of 723 patients with TN were selected from various departments by cluster sampling method,and 487 patients were finally determined to participate in the statistical analysis according to the inclusion and exclusion criteria.According to the quartile method,the TSH of the subjects was divided into four subgroups:low level,medium level,slightly higher level and high level.According to the diagnostic criteria of MS and BMI level,the population was divided into MS group and non-MS group,overweight group and non-overweight group,and the differences of indicators among different groups were compared.Logistic regression analysis was used to explore the independent risk factors of MS and the risk of MS with different TSH levels.The receiver operat-ing curve(ROC)was used to explore the value of TSH as a potential diagnostic marker for MS.Results:In TN,the detection rate of MS was 40.86％(199/487),and the detection rate of MS gradually increased with the increase of TSH level(trend x2=98.034,P＜0.001).Multivariate logistic regression analysis showed that TSH was an independent risk factor for MS,and the risk of MS in the high-level group was 11.014 times higher than that in the low-level TSH group.The ROC curve showed that the area under the curve(AUC)of TSH was 0.765,the optimal TSH cutoff value was 5.64 mIU/L,the sensitivity was 84.4％,and the specificity was 65.6％.The incidence of TN calcification in MS group and overweight group was higher than that in non-MS group and non-overweight group(P＜0.001).Conclu-sion:(1)In the TN population,TSH is an independent risk factor for MS and can be used as a potential predictor of MS occurrence.(2)MS or obese patients have a higher probability of deterioration of TN.
万方数据
维普
