Mechanism of action of mongolian medicine Chagan Wurile in treatment of chronic atrophic gastritis based on network pharmacology combined with molecular docking
Mechanism of action of mongolian medicine Chagan Wurile in treatment of chronic atrophic gastritis based on network pharmacology combined with molecular docking
Objective:To explore the mechanism of action of Mongolian medicine Chagan Wurile in the treatment of chronic atrophic gastritis(CAG)based on network pharmacology and molecular docking technique.Methods:The ac-tive components and action targets of three kinds of plant herbs were searched by TCMSP database;the related targets of chronic atrophic gastritis were collected from GeneCards,OMIM and Drugbank databases,and the common targets of Chagan Wurile and chronic atrophic gastritis were obtained by Venny online platform;the PPI network map of common targets was constructed by STRING11.5 database and Cytoscape3.9.1 software,and the key targets were screened out.The ClusterProfiler package of R language was used to analyze the enrichment of GO and KEGG pathways,and the Autodock Tools1.5.7 software was used to dock the core components with key targets.Results:A total of 28 active components and 512 targets of Chagan Wurile and 829 related targets of chronic atrophic gastritis were collected,with a total of 111 targets,which were mainly enriched in 720 biological functions and 20 signal pathways.Molecular docking showed that the core components kaempferol,isorhamnetin,quercetin,kaempferol,hesperetin and piperine had strong binding activity with key targets AKT1 and SRC.Conclusion:Chagan Wurile can protect gastric mucosa,against angio-genesis and regulate abnormal immunity.It may regulate cancer pathways,HIF-1 and other signaling pathways by act-ing on core targets such as AKT1 and SRC to treat CAG.
关键词
网络药理学/分子对接/作用机制/查干乌日勒/慢性萎缩性胃炎
Key words
Network pharmacology/Molecular docking/Mechanism of action/Chagan Wurile/Chronic atrophic gastritis
维普
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