Objective:To investigate the expression of CD34 and D2-40-labeled carcinoembryonic antigen M2 A in COAD tissues and its significance.Methods:The expression of CD34 and D2-40-labeled M2 A protein was detec-ted in 60 cases of COAD and 4 cases of adjacent normal tissues by immunohistochemical ElivisionTM plus method,and the density of CD34-positive microvessels and D2-40-positive microlymphatic vessels were counted respectively,and its relationship with COAD clinicopathological parameters were analyzed.Results:In COAD tissues,microvessel densi-ty and microlymphatic vessel density of positive CD34 and D2-40 were significantly higher than those in adjacent nor-mal tissues.The CD34 microvessel density in COAD tissue was related to the lesion site,the CD34 microvessel density in patients with right colon cancer was significantly higher than that in left colon cancer patients(P＜0.05).CD34 mi-crovessel density was positively correlated with D2-40 microvessel density in COAD tissues combining with mesenteric lymph node metastasis.Conclusion:CD34 and D2-40 labeled M2 A protein are highly expressed in COAD tissues,and they are positively correlated with mesenteric lymph node metastasis,suggesting that they may be synergistically in-volved in the occurrence of COAD lymph node metastasis.
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