首页|血清肿瘤标志物联合检测对肺癌诊断及病理分型的价值分析

血清肿瘤标志物联合检测对肺癌诊断及病理分型的价值分析

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目的:探讨血清肿瘤标志物单独及联合检测对肺癌诊断及分型的临床价值.方法:将蚌埠医学院第一附属医院呼吸与危重医学科2023年1月至10月收治的119例住院的肺癌患者作为研究组,另选取同期住院的肺部良性病变患者5 4例作为对照组,检测各组血清肿瘤标志物癌胚抗原(carcinoembryonic antigen,CEA)、鳞 状上皮细胞癌抗原(squamous cell carcinoma,SCC)、细胞角化蛋白19片段(cytokeratin 19 fragment,CYFRA21-1)、神经元特异性烯醇化酶(neuron-specific enolase,NSE)、胃泌素释放肤前体(pro-gastrin-releasing peptide,ProGRP)含量并进行组间指标比较和诊断效能分析.结果:肺癌组血清肿瘤标志物含量均高于对照组(P<0.05);腺癌组CEA含量高于鳞癌及小细胞癌组(P<0.05),鳞癌组SCC和CYFRA21-1含量高于腺癌及小细胞癌组(P<0.05),小细胞癌组NSE和ProGRP含量高于腺癌及鳞癌组(P<0.05);CEA检测腺癌的AUC较高(0.987),SCC和CYFRA21-1检测鳞癌的AUC较高(0.994和0.957),NSE和ProGRP检测小细胞癌的AUC较高(0.923和0.944),五项联合检测腺癌、鳞癌及小细胞癌组的AUC(0.991、0.997、0.996)均高于各组指标单独检测(P<0.05).结论:血清肿瘤标志物对于明确诊断肺癌及鉴别病理类型具有较高的指导价值,CEA对腺癌、SCC和CYFRA21-1对鳞癌、NSE和ProGRP对小细胞癌的诊断价值较高,联合上述各血清指标可提高不同病理类型肺癌的诊断效率.
Value of combined detection of serum tumor markers in the diagnosis and pathological classification of lung cancer
Objective:To evaluate the clinical value of serum tumor markers in the diagnosis and classification of lung cancer.Methods:A total of 119 patients with lung cancer admitted to the Department of Respiratory and Critical Care Medicine of the First Affiliated Hospital of Bengbu Medical College from January to October 2023 were selected as the study group,and 54 patients with benign lung tumors in the same period were selected as the control group.The con-tent of serum tumor markers carcinoembryonic antigen(CEA),squamous cell carcinoma antigen(SCC),cytokeratin fragment(CYFRA21-1),neuron-specific enolase(NSE)and gastrin-releasing peptide precursor(ProGRP)in each group was detected and the diagnostic efficacy was analyzed.Results:The serum tumor markers in the study group were higher than those in control group(P<0.05).The CEA content of adenocarcinoma group was higher than that of squamous cell carcinoma group and small cell carcinoma group(P<0.05),the contents of SCC and CYFRA21-1 in squamous cell carcinoma group were higher than those in the adenocarcinoma group and small cell carcinoma group(P<0.05),the levels of NSE and ProGRP in the small cell carcinoma group were higher than those in the adenocarcinoma group and squamous cell carcinoma group(P<0.05).The AUC of CEA detection for adenocarcinoma was 0.987,that of SCC and CYFRA21-1 detection for squamous cell carcinoma was 0.994 and 0.957,and that of NSE and ProGRP detection for small cell carcinoma was 0.923 and 0.944.The AUC(0.991,0.997,0.996)of the combined tests for adenocarcinoma,squamous cell carcinoma and small cell carcinoma were higher than those in separate tests(P<0.05).Conclusion:Serum tumor markers have a high guiding value in the definite diagnosis of lung cancer and the differ-entiation of pathological types.CEA has a high diagnostic value in adenocarcinoma,as well as SCC and CYFRA21-1 in squamous cell carcinoma,and NSE and ProGRP in small cell carcinoma.The combination of the above serum markers can improve the diagnostic efficiency of different pathological types of lung cancer.

Tumor markersLung cancerROC curveDiagnostic efficiency

马梦亭、冯杰、吴楠、张伦军

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蚌埠医学院第一附属医院检验科,安徽蚌埠 233000

蚌埠医学院第一附属医院神经外科

蚌埠医学院第一附属医院分子诊断中心

肿瘤标志物 肺癌 ROC曲线 诊断效能

安徽省教育厅重点项目

KJ2021A0799

2024

包头医学院学报
内蒙古科技大学包头医学院

包头医学院学报

影响因子:0.543
ISSN:1006-740X
年,卷(期):2024.40(10)
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