Changes of plasma metabolites and metabolic pathways in patients with left ventricular hypertrophy
Objective:To investigate the metabolic changes and possible metabolic pathways of hy-pertension with or without left ventricular hypertrophy(LVH)and healthy people.Methods:Thirty patients with hypertension(HTN)(HTN group),30 patients with hypertension and LVH(LVH group)and 30 healthy volunteers(control group)were recruited.The metabolic profiles of plasma samples were obtained by non-targeted metabolomics.Results:A total of 1141 metabolites were de-tected,of which 43 were significantly different only in LVH group and control group,such as leucine,adenine,magnolol and so on.Leucine and adenine were up-regulated in LVH patients.According to the analysis of KEGG pathway,a total of 22 differential metabolites were involved in the metabolic pathway of LVH.Compared with HTN group,linoleic acid metabolism and α-linolenic acid(α-li-nolenicacid,ALA)metabolic pathway were down-regulated in LVH group.Conclusion:Compared with healthy subjects,the metabolic spectrum of patients with LVH is significantly different,indicating that myocardial fatty acids may be protective factors of LVH,leucine and adenine may be risk factors of LVH,and LVH can be improved by α-linolenic acid metabolic pathway.
HypertensionHypertension with left ventricular hypertrophyNon-targeted meta-bonomics
万方数据
维普
