Objective:To analyze the effect of cone-beam computed tomography(CBCT)guided radiotherapy for malignant tumors.Methods:A total of 68 patients with malignant tumors who received radiotherapy from October 2021 to October 2022 were selected as the research objects.They were ran-domly divided into observation group and control group.Among them,34 patients in the observation group received CBCT-guided radiotherapy,with a frequency of 1 time/d.34 patients in the control group also received CBCT-guided radiotherapy,with a frequency of 1 time/3 d.The clinical effects of CBCT-guided methods were compared and analyzed.Results:The absolute values of x,y,z axis setup errors and setup expansion boundary in the observation group were lower than those in the control group(P<0.05).The maximum irradiation dose and average irradiation dose of malignant tumor pa-tients in the gross tumor area and planned target area in the observation group were higher than those in the control group(P<0.05).The objective effective rate of the observation group was higher than that of the control group(P<0.05).The quality of life scores in all fields of the observation group were higher than those of the control group(P<0.05).Conclusion:For patients with malignant tumors,CBCT scanning and guidance before treatment can reduce the positioning error during radio-therapy.With the increase of CBCT scanning frequency,the adaptability and accuracy of radiotherapy can be better improved,the treatment effect can be ensured,and the discomfort reaction can be pre-vented.