Relationship between obstructive sleep apnea and lung function and cognitive impairment
Objective:To investigate the correlation between obstructive sleep apnea(OSA)and lung function and cognitive impairment,and to investigate the possible mechanisms of lung function de-cline and cognitive impairment caused by OSA.Methods:Forty-six patients with obstructive sleep apnea hypopnea syndrome(OSAHS)diagnosed by polysomnography(PSG)from January 2021 to June 2022 were collected.According to the apnea hypopnea index(AHI),they were divided into mild to moderate group(n=20)and severe group(n=26).Healthy subjects(n=23)were selected as the control group.The general data,PSG,lung function,blood gas analysis,and Montreal Cognitive As-sessment Scale(MoCA)scores of the subjects were compared and statistically analyzed.Results:The vital capacity(VC),forced expiratory volume in 1 second percent predicted(FEV1％pred),forced expiratory volume in one second/forced vital capacity(FEV1/FVC％),expiratory reserve volume(ERV),functional residual capacity(FRC),maximum mid-expiratory flow rate(MMEF％)and 50％forced expiratory flow rate(FEF50％)in the severe group were lower than those in the mild-to-moderate group and the healthy group(P＜0.05).The partial pressure of oxygen(PaO2)in the severe group was lower than that in the mild to moderate group and the healthy group(P＜0.05).There was significant difference in MoCA score among the three groups(P＜0.05).Correlation analy-sis showed that PaO2 was negatively correlated with AHI and the longest apnea time,and positively correlated with LSaO2.Conclusion:The lung function and cognitive ability of OSA patients are im-paired,and the lung function and cognitive ability of patients with severe OSA are more obvious.Night hypoxia and low daytime PaO2 play an important role in the mechanism of lung function decline and cognitive impairment in OSA patients.
万方数据
维普
