摘要
目的:分析人乳头瘤病毒16型E6蛋白(Human papillomavirus type 16 E6 protein,HPV16-E6)、细胞分化抑制因子-1(Inhibitor of intracellular differentiation-1,ID-1)及脯氨酰顺反异构酶1(Prolylcis-trans isomerase 1,Pin1)在宫颈癌组织中的表达及相关性.方法:选择2017年3月至2022年3月莆田学院附属医院收治的宫颈癌65例,所有患者均在我院进行手术切除癌组织,并留取宫颈癌组织和距离癌组织边缘2 cm以上癌旁组织.通过免疫组化法对癌组织、癌旁组织标本HPV16-E6、ID-1、Pin1阳性表达率进行检测.分析HPV16-E6、ID-1、Pin1与临床特征的关系.结果:与癌旁组织相比,癌组织中HPV16-E6、ID-1、Pin1阳性率较高(P＜0.05).HPV16-E6、ID-1、Pin1与肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径呈正相关(P＜0.05).将年龄、病理类型等因素控制后,HPV16-E6、ID-1、Pin1与肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径相关(P＜0.05).结论:HPV16-E6、ID-1、Pin1在宫颈癌患者中均呈高表达,且HPV16-E6、ID-1、Pin1与宫颈癌患者肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径相关.
Abstract
Objective:To analyze the expression and correlation of human papillomavirus type 16 E6 protein(HPV16-E6),inhibitor of intracellular differentiation-1(ID-1)and prolylcis-trans isomerase1(Pin1)in cervical cancer.Methods:A total of 65 patients with cervical cancer admitted to the Affiliated Hospital of Putian University from March 2017 to March 2022 were selected.All pa-tients underwent surgical resection of cancer tissues in our hospital,and cervical cancer tissues and ad-jacent tissues more than 2 cm from the edge of cancer tissues were retained.The positive expression rates of HPV16-E6,ID-1 and Pin1 in cancer tissues and adjacent tissues were detected by immuno-histochemistry.The relationship between HPV16-E6,ID-1,Pin1 and clinical features was ana-lyzed.Results:Compared with adjacent tissues,the positive rates of HPV16-E6,ID-1 and Pin1 in cancer tissues were higher(P＜0.05).HPV 16-E6,ID-1 and Pin1 were positively correlated with depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor di-ameter(P＜0.05)..After controlling for age,pathological type and other factors,HPV16-E6,ID-1 and Pin1 were correlated with depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor diameter(P＜0.05).Conclusion:HPV16-E6,ID-1 and Pin1 are highly expressed in patients with cervical cancer,and HPV16-E6,ID-1 and Pin1 are related to the depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor diameter in patients with cervical cancer.
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