目的:分析人乳头瘤病毒16型E6蛋白(Human papillomavirus type 16 E6 protein,HPV16-E6)、细胞分化抑制因子-1(Inhibitor of intracellular differentiation-1,ID-1)及脯氨酰顺反异构酶1(Prolylcis-trans isomerase 1,Pin1)在宫颈癌组织中的表达及相关性.方法:选择2017年3月至2022年3月莆田学院附属医院收治的宫颈癌65例,所有患者均在我院进行手术切除癌组织,并留取宫颈癌组织和距离癌组织边缘2 cm以上癌旁组织.通过免疫组化法对癌组织、癌旁组织标本HPV16-E6、ID-1、Pin1阳性表达率进行检测.分析HPV16-E6、ID-1、Pin1与临床特征的关系.结果:与癌旁组织相比,癌组织中HPV16-E6、ID-1、Pin1阳性率较高(P＜0.05).HPV16-E6、ID-1、Pin1与肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径呈正相关(P＜0.05).将年龄、病理类型等因素控制后,HPV16-E6、ID-1、Pin1与肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径相关(P＜0.05).结论:HPV16-E6、ID-1、Pin1在宫颈癌患者中均呈高表达,且HPV16-E6、ID-1、Pin1与宫颈癌患者肌层浸润深度、组织学分级、临床分期、淋巴结转移、肿瘤直径相关.
Expression and correlation analysis of HPV16-E6,ID-1 and Pin1 in cervical cancer
Objective:To analyze the expression and correlation of human papillomavirus type 16 E6 protein(HPV16-E6),inhibitor of intracellular differentiation-1(ID-1)and prolylcis-trans isomerase1(Pin1)in cervical cancer.Methods:A total of 65 patients with cervical cancer admitted to the Affiliated Hospital of Putian University from March 2017 to March 2022 were selected.All pa-tients underwent surgical resection of cancer tissues in our hospital,and cervical cancer tissues and ad-jacent tissues more than 2 cm from the edge of cancer tissues were retained.The positive expression rates of HPV16-E6,ID-1 and Pin1 in cancer tissues and adjacent tissues were detected by immuno-histochemistry.The relationship between HPV16-E6,ID-1,Pin1 and clinical features was ana-lyzed.Results:Compared with adjacent tissues,the positive rates of HPV16-E6,ID-1 and Pin1 in cancer tissues were higher(P＜0.05).HPV 16-E6,ID-1 and Pin1 were positively correlated with depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor di-ameter(P＜0.05)..After controlling for age,pathological type and other factors,HPV16-E6,ID-1 and Pin1 were correlated with depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor diameter(P＜0.05).Conclusion:HPV16-E6,ID-1 and Pin1 are highly expressed in patients with cervical cancer,and HPV16-E6,ID-1 and Pin1 are related to the depth of myometrial invasion,histological grade,clinical stage,lymph node metastasis and tumor diameter in patients with cervical cancer.
Cervical cancerHuman papillomavirus type 16 E6 proteinInhibitor of intracellular differentiation-1Prolylcis-trans isomerase 1
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