The signage system of healthcare space plays a key role in medical environments,providing clear and convenient guidance for patients,visitors and staff.This paper discusses the evolution,development trend and design strategy of medical space signage design.The paper examines the evolution of medical space signage design from traditional guidance to functional,personalized and technological guidance.Then it emphasizes the application of clear and easy-to-understand guiding information,personalized service and digital technology,and points out that the intervention of artistic elements should be explored to empower the signage design.The continuous innovation of medical space signage design will enhance the comfort and service efficiency of the medical environment and provide patients with a better medical experience.