Poria cocos,as a medicinal and edible Chinese medicinal herb,is the dried sclerotium of Poria cocos(Schw.)Wolf(Polyporaceae).Studies on the chemical components of Poria cocos have led to the identification of various types of second-ary metabolites,including tetracyclic triterpenoids,polysaccharides and sterols,and so on.Meanwhile,it has a wide range of bi-ological activities,such as diuretic,invigorating the spleen,antidiarrheic,calming the nerves,anti-inflammatory,lipid-decrea-sing,hepatoprotective and anti-tumor activities.It is widely used in the clinical treatment of edema,inflammation,disorders of glucose and lipid metabolism and other diseases.In this paper,the chemical constituents,pharmacological effects and clinical applications of Poriacocosare were reviewed to provide references for further research and clinical application.