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盐炙黄芪的质量标准

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目的 建立盐炙黄芪质量标准.方法 分别采用显微鉴别、薄层色谱法对盐炙黄芪进行鉴别,按 2020 年版《中国药典》通则方法测定水分、浸出物和总灰分的含量,HPLC法测定黄芪甲苷和毛蕊异黄酮葡萄糖苷含量.结果 药材显微特征明显,薄层色谱法鉴别斑点清晰,专属性良好.水分、浸出物和总灰分的平均含量分别为 4.5%、35.3%和4.0%.黄芪甲苷在 1.08～10.8 μg范围内线性关系良好(R2 =0.999 4),平均回收率为96.2%,盐炙黄芪中黄芪甲苷含量不得少于0.050%.毛蕊异黄酮葡萄糖苷在 10.6～212.0 μg/mL范围内线性关系良好(R2 =0.999 6),平均回收率为96.0%,盐炙黄芪中毛蕊异黄酮葡萄糖苷不得少于0.020%.结论 本研究制订了盐炙黄芪的质量标准,可用于盐炙黄芪的质量控制和相关产品的检验.
Quality standard for Astragali Radix Praeparata Cum Melle by salt
Objective To establish the quality standard of Astragali Radix Praeparata Cum Melle by salt.Methods The methods of microscopic identification and thin layer chromatography(TLC)were used to identify Astragali Radix Praeparata Cum Melle by salt.The contents of moisture,extract,and total ash were detected according to Chinese Pharmacopoeia(2020 Edi-tion).The contents of Astragaloside IV and calycosin-7-O-β-D-glucoside were determined by high performance liquid chromatog-raphy.Results The microscopic characteristics was apparent,and the spots of TLC were distinct.The average content of mois-ture,extract,and total ash were 4.5,35.3%and 4.0%,respectively.The linearity of Astragaloside IV(1.08-10.8μg)and calycosin-7-O-β-D-glucoside(10.6-212.0 μg/mL)was good(R2 =0.999 4,and R2 =0.999 6,respectively).The average re-covery of Astragaloside IV and calycosin-7-O-β-D-glucoside was 96.2%and 96.0%,respectively.The content of Astragaloside IV and calycosin-7-O-β-D-glucoside should not be less than 0.050%and 0.020,respectively.Conclusion This study estab-lished a complete standard of Astragali Radix Praeparata Cum Melle by salt,which could be applied to the quality control of As-tragali Radix Praeparata Cum Melle by salt and the test of related product.

Astragali Radix Praeparata Cum Melle by saltquality standardidentificationcontent determination

徐倩倩、王丽、张婉莹、刘华博、西祥瑞、魏鑫、张加余、赵娟娟

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滨州医学院药学院 山东 烟台 264003

盐炙黄芪 质量标准 鉴别 含量测定

国家科学自然基金国家科学自然基金山东省自然科学基金泰山学者青年专家项目国家级大学生创新创业训练计划山东省中医药科技发展计划山东省中医药科技项目

8217403981803494ZR2020MH371tsqn202103110S2022104400192017-225Z-2022085

2024

10.19739/j.cnki.issn1001-9510.2024.02.001

滨州医学院学报
滨州医学院

滨州医学院学报

影响因子：0.548
ISSN：1001-9510
年,卷(期)：2024.47(2)
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